Retinoic acid (RA) signaling plays an important role during heart development in
establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and …

Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple
cardiac cell lineages during embryonic development and provides signals that are essential …

Using four-dimensional whole-embryo light sheet imaging with improved and accessible
computational tools, we longitudinally reconstruct early murine cardiac development at …

The heart, which is the first organ to develop, is highly dependent on its form to function 1, 2.
However, how diverse cardiac cell types spatially coordinate to create the complex …

The mammalian heart arises from various populations of Mesp1-expressing cardiovascular
progenitors (CPs) that are specified during the early stages of gastrulation. Mesp1 is a …

Decreased left ventricle (LV) function caused by genetic mutations or injury often leads to
debilitating and fatal cardiovascular disease. LV cardiomyocytes are, therefore, a potentially …

Congenital heart disease (CHD) affects~ 1% of all live births, but a definitive etiology is
identified in only~ 50%. The causes include chromosomal aneuploidies and copy-number …

Heart morphogenesis is a complex and dynamic process that has captivated researchers for
almost a century. This process involves three main stages, during which the heart …

Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor
populations. Understanding the specification and differentiation of these distinct progenitor …