Possibilities and challenges for developing a successful vaccine for leishmaniasis
Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …
Pathogenesis of chagas' disease: parasite persistence and autoimmunity
ARL Teixeira, MM Hecht, MC Guimaro… - Clinical microbiology …, 2011 - Am Soc Microbiol
Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected
individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast …
individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast …
The immunology of post-kala-azar dermal leishmaniasis (PKDL)
EE Zijlstra - Parasites & vectors, 2016 - Springer
Post-kala-azar dermal leishmaniasis (PKDL) is a common complication of visceral
leishmaniasis (VL) caused by Leishmania donovani. Because of its possible role in …
leishmaniasis (VL) caused by Leishmania donovani. Because of its possible role in …
Immune regulation during chronic visceral leishmaniasis
RJ Faleiro, R Kumar, LM Hafner… - PLoS neglected tropical …, 2014 - journals.plos.org
Visceral leishmaniasis is a chronic parasitic disease associated with severe immune
dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine …
dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine …
[HTML][HTML] Post kala-azar dermal leishmaniasis: an unresolved mystery
D Mukhopadhyay, JE Dalton, PM Kaye… - Trends in …, 2014 - cell.com
Post kala-azar dermal leishmaniasis (PKDL), a cutaneous sequela of visceral leishmaniasis
(VL), develops in some patients alongside but more commonly after apparent cure from VL …
(VL), develops in some patients alongside but more commonly after apparent cure from VL …
Post kala-azar dermal leishmaniasis: A threat to elimination program
Leishmaniasis remains a public health concern around the world that primarily affects poor
folks of the developing world spanning across 98 countries with mortality of 0.2 million to 0.4 …
folks of the developing world spanning across 98 countries with mortality of 0.2 million to 0.4 …
Targeted killing of Leishmania donovani in vivo and in vitro with amphotericin B attached to functionalized carbon nanotubes
VK Prajapati, K Awasthi, S Gautam… - Journal of …, 2011 - academic.oup.com
Objectives This study describes the antileishmanial efficacy of the novel drug formulation of
amphotericin B (AmB) attached to functionalized carbon nanotubes (f-CNTs) and compares …
amphotericin B (AmB) attached to functionalized carbon nanotubes (f-CNTs) and compares …
Quantification of parasite load in clinical samples of leishmaniasis patients: IL-10 level correlates with parasite load in visceral leishmaniasis
A rapid and accurate method to detect and quantify Leishmania parasite is urgently needed
to facilitate early diagnosis of Leishmaniasis and monitoring of antileishmania therapy. In …
to facilitate early diagnosis of Leishmaniasis and monitoring of antileishmania therapy. In …
M2 polarization of monocytes-macrophages is a hallmark of Indian post kala-azar dermal leishmaniasis
D Mukhopadhyay, S Mukherjee, S Roy… - PLoS neglected …, 2015 - journals.plos.org
The high level of functional diversity and plasticity in monocytes/macrophages has been
defined within in vitro systems as M1 (classically activated), M2 (alternatively activated) and …
defined within in vitro systems as M1 (classically activated), M2 (alternatively activated) and …
The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis
MA Hartley, S Drexler, C Ronet, SM Beverley… - Trends in …, 2014 - cell.com
Cutaneous leishmaniases have persisted for centuries as chronically disfiguring parasitic
infections affecting millions of people across the subtropics. Symptoms range from the more …
infections affecting millions of people across the subtropics. Symptoms range from the more …