[HTML][HTML] Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients
A Provenzani, A Santeusanio, E Mathis… - World Journal of …, 2013 - ncbi.nlm.nih.gov
The introduction of tacrolimus in clinical practice has improved patient survival after organ
transplant. However, despite the long use of tacrolimus in clinical practice, the best way to …
transplant. However, despite the long use of tacrolimus in clinical practice, the best way to …
Effect of CYP3A4* 22, CYP3A5* 3, and CYP3A combined genotypes on cyclosporine, everolimus, and tacrolimus pharmacokinetics in renal transplantation
D Moes, JJ Swen, J Den Hartigh… - CPT …, 2014 - Wiley Online Library
Cyclosporine, everolimus, and tacrolimus are the cornerstone of immunosuppressive
therapy in renal transplantation. These drugs are characterized by narrow therapeutic …
therapy in renal transplantation. These drugs are characterized by narrow therapeutic …
Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium–Based Treatment in Brazilian Kidney Transplant Recipients
FDV Genvigir, AM Nishikawa, CR Felipe… - … : The Journal of …, 2017 - Wiley Online Library
Study Objective To investigate the influence of single nucleotide polymorphisms (SNP s) in
genes encoding metabolizing enzymes (CYP 2C8, CYP 2J2, and UGT 2B7) and …
genes encoding metabolizing enzymes (CYP 2C8, CYP 2J2, and UGT 2B7) and …
[HTML][HTML] Impact of single nucleotide polymorphisms (SNPs) on immunosuppressive therapy in lung transplantation
Lung transplant patients present important variability in immunosuppressant blood
concentrations during the first months after transplantation. Pharmacogenetics could explain …
concentrations during the first months after transplantation. Pharmacogenetics could explain …
Role of pharmacogenomics in dialysis and transplantation
K Birdwell - Current opinion in nephrology and hypertension, 2014 - journals.lww.com
Role of pharmacogenomics in dialysis and transplantation : Current Opinion in Nephrology and
Hypertension Role of pharmacogenomics in dialysis and transplantation : Current Opinion in …
Hypertension Role of pharmacogenomics in dialysis and transplantation : Current Opinion in …
The importance of MDR1 gene polymorphisms for tacrolimus dosage
M Kravljaca, V Perovic, V Pravica, V Brkovic… - European Journal of …, 2016 - Elsevier
Polymorphisms of the multi drug resistance (MDR1) gene cause variability in P-glycoprotein
mediated metabolism of tacrolimus. The aim of this study was to examine the relationship …
mediated metabolism of tacrolimus. The aim of this study was to examine the relationship …
CYP3A5 genotype affects time to therapeutic tacrolimus level in pediatric kidney transplant recipients
MV Yanik, ME Seifert, JE Locke… - Pediatric …, 2019 - Wiley Online Library
Background Optimal management of immunosuppression in kidney transplantation requires
a delicate balance of efficacy and toxicity. Tacrolimus (TAC) dose requirements are …
a delicate balance of efficacy and toxicity. Tacrolimus (TAC) dose requirements are …
Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients
Calcineurin-inhibitors CI are immunosuppressive agents prescribed to patients after solid
organ transplant to prevent rejection. Although these drugs have been transformative for …
organ transplant to prevent rejection. Although these drugs have been transformative for …
NFATC1 Genotypes Affect Acute Rejection and Long-Term Graft Function in Cyclosporine-Treated Renal Transplant Recipients
Q Xu, X Qiu, Z Jiao, M Zhang, J Chen… - Pharmacogenomics, 2017 - Taylor & Francis
Aim: To investigate the effects of SNPs in the cyclophilin A/calcineurin/nuclear factor of
activated T-cells (NFATs) pathway genes (PPIA, PPP3CB, PPP3R1, NFATC1 and NFATC2) …
activated T-cells (NFATs) pathway genes (PPIA, PPP3CB, PPP3R1, NFATC1 and NFATC2) …
Influence of uridine diphosphate-glucuronosyltransferases (1A9) polymorphisms on mycophenolic acid pharmacokinetics in patients with renal transplant
Background: There are differences in pharmacokinetic of mycophenolic acid among
individuals. The UGT1A9 enzyme is of special interest since it is the main enzyme involved …
individuals. The UGT1A9 enzyme is of special interest since it is the main enzyme involved …