High-throughput glycomic methods

I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

Oligosaccharide analysis by mass spectrometry: a review of recent developments

MJ Kailemia, LR Ruhaak, CB Lebrilla… - Analytical …, 2014 - ACS Publications
Carbohydrates are central players in a number of important biological processes including
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …

Mass spectrometry imaging with laser-induced postionization

J Soltwisch, H Kettling, S Vens-Cappell, M Wiegelmann… - Science, 2015 - science.org
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can
simultaneously record the lateral distribution of numerous biomolecules in tissue slices, but …

Mass spectrometry in the analysis of N-linked and O-linked glycans

SJ North, PG Hitchen, SM Haslam, A Dell - Current opinion in structural …, 2009 - Elsevier
Mass spectrometry (MS) continues to play a vital role in defining the structures of N-glycans
and O-glycans in glycoproteins via glycomic and glycoproteomic methodologies. The former …

Developments in mass spectrometry for glycosaminoglycan analysis: a review

LE Pepi, P Sanderson, M Stickney, IJ Amster - Molecular & Cellular …, 2021 - ASBMB
This review covers recent developments in glycosaminoglycan (GAG) analysis via mass
spectrometry (MS). GAGs participate in a variety of biological functions, including cellular …

Concept, strategy and realization of lectin-based glycan profiling

J Hirabayashi - Journal of biochemistry, 2008 - academic.oup.com
Lectins are a diverse group of carbohydrate-binding proteins. Each lectin has its own
specificity profile. It is believed that lectins exist in all living organisms that produce glycans …

Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans

R Lawrence, H Lu, RD Rosenberg, JD Esko, L Zhang - Nature methods, 2008 - nature.com
Here we introduce a new shorthand nomenclature for designating the disaccharide subunit
structure of all glycosaminoglycans as a way to compare compositions and describe linear …

Ionic liquids in analytical chemistry

RJ Soukup-Hein, MM Warnke… - Annual Review of …, 2009 - annualreviews.org
The role of ionic liquids (ILs) in analytical chemistry is increasing substantially every year. A
decade ago there were but a handful of papers in this area of research that were considered …

Ionic liquids for mass spectrometry: matrices, separation and microextraction

HN Abdelhamid - TrAC Trends in Analytical Chemistry, 2016 - Elsevier
Applications of ionic liquids (ILs) for mass spectrometry (MS) are a burgeoning area and are
promising for real applications. However, the research of ILs for MS is in its infancy and there …

Heparin characterization: challenges and solutions

CJ Jones, S Beni, JFK Limtiaco… - Annual review of …, 2011 - annualreviews.org
Although heparin is an important and widely prescribed pharmaceutical anticoagulant, its
high degree of sequence microheterogeneity and size polydispersity make molecular-level …