ABSTRACT Introduction Soft mist inhalers (SMIs) are propellant-free inhalers that utilize
mechanical power to deliver single or multiple doses of inhalable drug aerosols in the form …

Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …

Purpose CFD provides a powerful approach to evaluate the deposition of pharmaceutical
aerosols; however, previous studies have not compared CFD results of deposition …

This article reviews recent developments in computational modeling of dry powder inhalers
(DPIs). DPIs deliver drug formulations (sometimes blended with larger carrier particles) to a …

Background: In vitro—in vivo correlations (IVIVC) for lung deposition may be established by
testing inhalers in vitro with realistic mouth–throat (MT) models and inhalation profiles (IP) …

Background: The objective of this study was to compare aerosol deposition predictions of a
new whole-airway CFD model with available in vivo data for a dry powder inhaler (DPI) …

Conventional in vitro tests to assess the aerodynamic particle size distribution (APSD) from
inhaler devices use simple right-angle inlets (“mouth-throats”, MTs) to cascade impactors …

The relative position between the pediatric upper airway and the inhalation device during
real inhalation administration has significant effects on the delivery efficiency of orally …

There is a growing need to select a realistic mouth–throat (MT) model to replace the USP
induction port (IP) which underestimates MT deposition of inhaled particles. Even though …

While dry powder aerosol formulations offer a number of advantages, their use in children is
often limited due to poor lung delivery efficiency and difficulties with consistent dry powder …