Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin
regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear …

Effective pharmacological management of pain associated with tissue pathology is an unmet
medical need. Transcriptional modifications in nociceptive pathways are pivotal for the …

A major goal in the field of transcriptional regulation is the mapping of changes in the
binding of transcription factors to the resultant changes in gene expression. Recently …

The human genome contains millions of candidate cis-regulatory elements (CREs) with cell-
type-specific activities that shape both health and myriad disease states. However, we lack a …

The prevalence of type 2 diabetes mellitus (T2DM) continues to rise globally. Yet the
aetiology and pathophysiology of this noncommunicable, polygenic disease, is poorly …

Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …

Single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) is
rapidly becoming a powerful technology for assessing the epigenetic landscape of …

Enhancers are non‐coding DNA elements that play a crucial role in enhancing the
transcription rate of a specific gene in the genome. Experiments for identifying enhancers …

Hormones control developmental and physiological processes, often by regulating the
expression of multiple genes simultaneously or sequentially. Crosstalk between hormones …

Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …