Heterogeneity and treatment landscape of ovarian carcinoma
AC Veneziani, E Gonzalez-Ochoa, H Alqaisi… - Nature Reviews …, 2023 - nature.com
Ovarian carcinoma is characterized by heterogeneity at the molecular, cellular and
anatomical levels, both spatially and temporally. This heterogeneity affects response to …
anatomical levels, both spatially and temporally. This heterogeneity affects response to …
[HTML][HTML] Prevention, screening, treatment and follow-up of gynecological cancers: state of art and future perspectives
TG D'Augè, A Giannini, G Bogani, C Di Dio… - Clinical and …, 2023 - imrpress.com
Objective: This study aims to analyze the available data on prevention and early diagnosis
in gynecological cancers. Mechanism: A comprehensive search was performed in the …
in gynecological cancers. Mechanism: A comprehensive search was performed in the …
CT-based radiomics and deep learning for BRCA mutation and progression-free survival prediction in ovarian cancer using a multicentric dataset
G Avesani, HE Tran, G Cammarata, F Botta… - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer has a heterogeneous response to treatment, and relapse
may vary considerably. Different studies investigated the role of radiomics in ovarian cancer …
may vary considerably. Different studies investigated the role of radiomics in ovarian cancer …
Expanding the Role of Boron in New Drug Chemotypes: Properties, Chemistry, Pharmaceutical Potential of Hemiboronic Naphthoids
MZH Kazmi, OM Schneider, DG Hall - Journal of Medicinal …, 2023 - ACS Publications
New chemotypes and bioisosteres can open a new chemical space in drug discovery and
help meet an urgent demand for novel agents to fight infections and other diseases. With the …
help meet an urgent demand for novel agents to fight infections and other diseases. With the …
PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages
DV Santinelli-Pestana, E Aikawa, SA Singh, M Aikawa - Pathogens, 2023 - mdpi.com
Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is
associated with multiple disease processes such as infections and chronic inflammatory …
associated with multiple disease processes such as infections and chronic inflammatory …
Role of PARP inhibitors in cancer immunotherapy: potential friends to immune activating molecules and foes to immune checkpoints
O Franzese, G Graziani - Cancers, 2022 - mdpi.com
Simple Summary This review aims at analyzing an emergent topic regarding the possible
combined use of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), anticancer drugs …
combined use of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), anticancer drugs …
Immunotherapeutic approaches in ovarian cancer
H Yoon, A Kim, H Jang - Current Issues in Molecular Biology, 2023 - mdpi.com
Ovarian cancer (OC) is gynecological cancer, and diagnosis and treatment are continuously
advancing. Next-generation sequencing (NGS)-based diagnoses have emerged as novel …
advancing. Next-generation sequencing (NGS)-based diagnoses have emerged as novel …
Neoadjuvant Chemotherapy plus Interval Cytoreductive Surgery with or without Hyperthermic Intraperitoneal Chemotherapy (NIHIPEC) in the Treatment of Advanced …
Simple Summary Advanced ovarian cancer (Stages III-IV) continues to be one of the
gynecological tumors with the highest mortality. Standard treatment consists of debulking …
gynecological tumors with the highest mortality. Standard treatment consists of debulking …
Addition of niraparib to best supportive care as maintenance treatment in patients with advanced urothelial carcinoma whose disease did not progress after first-line …
F Vignani, R Tambaro, U De Giorgi, P Giannatempo… - European urology, 2023 - Elsevier
Background Platinum-based chemotherapy (PBCT) is the standard first-line treatment for
advanced urothelial carcinoma (UC). Potential cross-sensitivity can be hypothesized …
advanced urothelial carcinoma (UC). Potential cross-sensitivity can be hypothesized …
British Gynaecological Cancer Society recommendations for evidence based, population data derived quality performance indicators for ovarian cancer
Simple Summary Ovarian cancer survival in the UK is poorer than other similar countries.
Results from the National Ovarian Cancer Audit Feasibility Pilot (OCAFP) showed that …
Results from the National Ovarian Cancer Audit Feasibility Pilot (OCAFP) showed that …