The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …

Environmental nutrient availability influences T cell metabolism, impacting T cell function
and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β …

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …

Histone post-translational modifications (HPTMs) are essential epigenetic mechanisms that
affect chromatin-associated nuclear processes without altering the DNA sequence. With the …

Objective Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic
fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG …

Cisplatin, as a commonly used anticancer drug, can easily lead to acute kidney injury (AKI),
and has received more and more attention in clinical practice. β-hydroxybutyric acid (BHB) is …

Prospective molecular targets and therapeutic applications for ketone body metabolism
have increased exponentially in the past decade. Initially considered to be restricted in …

Blood vessel formation is dependent on metabolic adaption in endothelial cells. Glucose
and fatty acids are essential substrates for ATP and biomass production; however, the …

In population studies, dietary patterns clearly influence the development, progression, and
therapeutic response of cancers. Nonetheless, interventional dietary trials have had …