Understanding how the genome is structurally organized as chromatin is essential for
understanding its function. Here, we review recent developments that allowed the …

Experimental approaches have been applied to address questions in understanding three-
dimensional chromatin organization and function. As datasets increase in size and …

Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …

Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …

The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …

Biomolecular phase separation denotes the demixing of a specific set of intracellular
components without membrane encapsulation. Recent studies have found that biomolecular …

Nucleosomes cluster together when chromatin folds in the cell to form heterogeneous
groups termed “clutches”. These structural units add another level of chromatin regulation …

In our cells, DNA is folded and packed with the help of many proteins into chromatin whose
basic unit is a nucleosome—DNA wrapped around octamer of histone proteins. The chain of …

The three-dimensional organisation of the genome modulates biological processes and is,
in turn, transformed by the activity in the nucleus. Not surprisingly, understanding how the …

Chromatin can be viewed as a hierarchically structured fiber that regulates gene expression.
It consists of a complex network of DNA and proteins whose characteristic dynamical modes …