African genetic diversity and adaptation inform a precision medicine agenda
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …
humans more than 300,000 years ago, has resulted in high genetic diversity and …
Evaluating the promise of inclusion of African ancestry populations in genomics
AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …
known, and the resultant scientific and ethical limitations are becoming increasingly …
Regional patterns and association between obesity and hypertension in Africa: evidence from the H3Africa CHAIR study
Hypertension and obesity are the most important modifiable risk factors for cardiovascular
diseases, but their association is not well characterized in Africa. We investigated regional …
diseases, but their association is not well characterized in Africa. We investigated regional …
Non-communicable diseases pandemic and precision medicine: Is Africa ready?
Non-communicable diseases (NCDs) kill more than 41 million people every year,
accounting for 71% of all deaths globally. The prevalence of NCDs is estimated to be higher …
accounting for 71% of all deaths globally. The prevalence of NCDs is estimated to be higher …
African genomes hold the key to accurate genetic risk prediction
The majority of polygenic risk scores (PRS)(also known as polygenic scores, genetic risk
scores or polygenic indexes) have been generated and optimized in peoples of European …
scores or polygenic indexes) have been generated and optimized in peoples of European …
Frequent vegetable consumption is inversely associated with hypertension among indigenous Africans
Aims The relationship between vegetable consumption and hypertension occurrence
remains poorly characterized in sub-Saharan Africa. This study assessed the association of …
remains poorly characterized in sub-Saharan Africa. This study assessed the association of …
Post-surgery survival and associated factors for cardiac patients in Ethiopia: applications of machine learning, semi-parametric and parametric modelling
Introduction Living in poverty, especially in low-income countries, are more affected by
cardiovascular disease. Unlike the developed countries, it remains a significant cause of …
cardiovascular disease. Unlike the developed countries, it remains a significant cause of …
Genomics in Egypt: current status and future aspects
EA El-Attar, RM Helmy Elkaffas, SA Aglan… - Frontiers in …, 2022 - frontiersin.org
Egypt is the third most densely inhabited African country. Due to the economic burden and
healthcare costs of overpopulation, genomic and genetic testing is a huge challenge …
healthcare costs of overpopulation, genomic and genetic testing is a huge challenge …
Human height: a model common complex trait
M Conery, SFA Grant - Annals of human biology, 2023 - Taylor & Francis
Context Like other complex phenotypes, human height reflects a combination of
environmental and genetic factors, but is notable for being exceptionally easy to measure …
environmental and genetic factors, but is notable for being exceptionally easy to measure …
Factors associated with frequency of fruit and vegetable consumption among selected sub-Saharan African populations: evidence from the Cardiovascular H3Africa …
Background Frequent fruit and vegetable consumption is considered a promising dietary
behaviour that protects health. However, most existing studies about the factors associated …
behaviour that protects health. However, most existing studies about the factors associated …