African genetic diversity and adaptation inform a precision medicine agenda

L Pereira, L Mutesa, P Tindana, M Ramsay - Nature Reviews Genetics, 2021 - nature.com
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

Evaluating the promise of inclusion of African ancestry populations in genomics

AR Bentley, SL Callier, CN Rotimi - NPJ genomic medicine, 2020 - nature.com
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …

Regional patterns and association between obesity and hypertension in Africa: evidence from the H3Africa CHAIR study

OM Akpa, F Made, A Ojo, B Ovbiagele, D Adu… - …, 2020 - Am Heart Assoc
Hypertension and obesity are the most important modifiable risk factors for cardiovascular
diseases, but their association is not well characterized in Africa. We investigated regional …

Non-communicable diseases pandemic and precision medicine: Is Africa ready?

T Chikowore, AB Kamiza, OH Oduaran, T Machipisa… - …, 2021 - thelancet.com
Non-communicable diseases (NCDs) kill more than 41 million people every year,
accounting for 71% of all deaths globally. The prevalence of NCDs is estimated to be higher …

African genomes hold the key to accurate genetic risk prediction

S Fatumo, M Inouye - Nature Human Behaviour, 2023 - nature.com
The majority of polygenic risk scores (PRS)(also known as polygenic scores, genetic risk
scores or polygenic indexes) have been generated and optimized in peoples of European …

Frequent vegetable consumption is inversely associated with hypertension among indigenous Africans

OM Akpa, AP Okekunle, OJ Asowata… - European journal of …, 2022 - academic.oup.com
Aims The relationship between vegetable consumption and hypertension occurrence
remains poorly characterized in sub-Saharan Africa. This study assessed the association of …

Post-surgery survival and associated factors for cardiac patients in Ethiopia: applications of machine learning, semi-parametric and parametric modelling

M Tadege, AS Tegegne, ZG Dessie - BMC Medical Informatics and …, 2024 - Springer
Introduction Living in poverty, especially in low-income countries, are more affected by
cardiovascular disease. Unlike the developed countries, it remains a significant cause of …

Genomics in Egypt: current status and future aspects

EA El-Attar, RM Helmy Elkaffas, SA Aglan… - Frontiers in …, 2022 - frontiersin.org
Egypt is the third most densely inhabited African country. Due to the economic burden and
healthcare costs of overpopulation, genomic and genetic testing is a huge challenge …

Human height: a model common complex trait

M Conery, SFA Grant - Annals of human biology, 2023 - Taylor & Francis
Context Like other complex phenotypes, human height reflects a combination of
environmental and genetic factors, but is notable for being exceptionally easy to measure …

Factors associated with frequency of fruit and vegetable consumption among selected sub-Saharan African populations: evidence from the Cardiovascular H3Africa …

AP Okekunle, OJ Asowata, OM Akpa… - International Journal …, 2024 - academic.oup.com
Background Frequent fruit and vegetable consumption is considered a promising dietary
behaviour that protects health. However, most existing studies about the factors associated …