Multiple endocrine neoplasia type 1 (MEN1): an update and the significance of early genetic and clinical diagnosis

CDC Kamilaris, CA Stratakis - Frontiers in endocrinology, 2019 - frontiersin.org
Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumor syndrome inherited in
an autosomal dominant manner and characterized by a predisposition to a multitude of …

Molecular genetics of multiple endocrine neoplasia types 1 and 2

SJ Marx - Nature Reviews Cancer, 2005 - nature.com
Six multiple endocrine neoplasia (MEN) syndromes have received a level of attention that
might seem disproportionate to their low prevalence. The attention has been given because …

Clinical characterization of familial isolated pituitary adenomas

AF Daly, ML Jaffrain-Rea, A Ciccarelli… - The Journal of …, 2006 - academic.oup.com
Context: Familial pituitary adenomas occur rarely in the absence of multiple endocrine
neoplasia type 1 (MEN1) and Carney complex (CNC). Objective: Our objective was to …

The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and …

CA Stratakis, MA Tichomirowa, S Boikos… - Clinical …, 2010 - Wiley Online Library
Stratakis CA, Tichomirowa MA, Boikos S, Azevedo MF, Lodish M, Martari M, Verma S, Daly
AF, Raygada M, Keil MF, Papademetriou J, Drori‐Herishanu L, Horvath A, Tsang KM …

Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and …

N Garbrecht, M Anlauf, A Schmitt… - Endocrine-Related …, 2008 - erc.bioscientifica.com
Somatostatin-producing neuroendocrine tumors (SOM-NETs) of the duodenum and
pancreas appear to be heterogeneous. To determine their clinicopathological profiles …

The clinical, pathological, and genetic features of familial isolated pituitary adenomas

A Beckers, AF Daly - European Journal of Endocrinology, 2007 - academic.oup.com
Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1)
and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and …

[HTML][HTML] The future: genetics advances in MEN1 therapeutic approaches and management strategies

SK Agarwal - Endocrine-related cancer, 2017 - ncbi.nlm.nih.gov
The identification of the multiple endocrine neoplasia type 1 (MEN1) gene in 1997 has
shown that germline heterozygous mutations in the MEN1 gene located on chromosome …

Biomarkers for pancreatic neuroendocrine neoplasms (PanNENs) management—an updated review

M Bocchini, F Nicolini, S Severi, A Bongiovanni… - Frontiers in …, 2020 - frontiersin.org
Pancreatic neuroendocrine tumors (PanNENs) are rare sporadic cancers or develop as part
of hereditary syndromes. PanNENs can be both functioning and non-functioning based on …

Phenotypes associated with MEN1 syndrome: a focus on genotype-phenotype correlations

C Mele, M Mencarelli, M Caputo, S Mai… - Frontiers in …, 2020 - frontiersin.org
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant inherited tumor
syndrome, associated with parathyroid, pituitary, and gastro-entero-pancreatic (GEP) …

Hereditary neuroendocrine tumors of the gastroenteropancreatic system

M Anlauf, N Garbrecht, J Bauersfeld, A Schmitt… - Virchows Archiv, 2007 - Springer
Abstract Approximately 5–10% of neuroendocrine tumors (NETs) of the
gastroenteropancreatic system (GEP) have a hereditary background. The known inherited …