Coronary artery disease (CAD) and its complications are the leading cause of death
worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the …

The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …

Drug combinations can expand options for antibacterial therapies but have not been
systematically tested in Gram-positive species. We profiled~ 8,000 combinations of 65 …

In order to assess the significance of drug/substance levels measured in intensive care
medicine and clinical and forensic toxicology as well as for therapeutic drug monitoring, it is …

Background Gabapentinoid (pregabalin and gabapentin) abuse is increasingly being
reported. Objective To assess the extent of gabapentinoid abuse, characteristics of typical …

Background: Studies of out-of-hospital cardiac arrest and sudden cardiac death (SCD) use
emergency medical services records, death certificates, or definitions that infer cause of …

Pharmaceuticals have been considered 'contaminants of emerging concern'for more than 20
years. In that time, many laboratory studies have sought to identify hazard and assess risk in …

In the last ten years, gabapentin and pregabalin have been becoming dispensed broadly
and sold on black markets, thereby, exposing millions to potential side-effects. Meanwhile …