Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …

Macrophages have diverse phenotypes and functions due to differences in their origin,
location and pathophysiological context. Although their main role in the liver has been …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

Tissue-resident and recruited macrophages contribute to both host defense and pathology.
Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep …

Liver cirrhosis is a major cause of death worldwide and is characterized by extensive
fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better …

Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid
peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive …

Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …