Chemistry of lipid nanoparticles for RNA delivery
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
Nanoparticle-based medicines in clinical cancer therapy
S Wang, K Cheng, K Chen, C Xu, P Ma, G Dang… - Nano Today, 2022 - Elsevier
Anti-cancer drugs with various mechanisms emerge in succession, but most of free
therapeutics are accompanied by some disadvantages, such as poor safety and …
therapeutics are accompanied by some disadvantages, such as poor safety and …
Evolution of drug delivery systems: From 1950 to 2020 and beyond
H Park, A Otte, K Park - Journal of Controlled Release, 2022 - Elsevier
Modern drug delivery technology began in 1952 with the advent of the Spansule® sustained-
release capsule technology, which can deliver a drug for 12 h after oral administration …
release capsule technology, which can deliver a drug for 12 h after oral administration …
[HTML][HTML] Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging
Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles
that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …
that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid …
[HTML][HTML] Structure and function of cationic and ionizable lipids for nucleic acid delivery
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and
become major health issues, but the treatment development remains challenging. Gene …
become major health issues, but the treatment development remains challenging. Gene …
Lipid nanoparticle-mediated drug delivery to the brain
Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …
Developing biodegradable lipid nanoparticles for intracellular mRNA delivery and genome editing
Conspectus Since the US Food and Drug Administration (FDA) granted emergency use
authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has …
authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has …
[HTML][HTML] The use of RNA-based treatments in the field of cancer immunotherapy
M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
Lipid nanoparticle technologies for nucleic acid delivery: A nanoarchitectonics perspective
Lipid‐based nanoparticles have emerged as a clinically viable platform technology to
deliver nucleic acids for a wide range of healthcare applications. Within this scope, one of …
deliver nucleic acids for a wide range of healthcare applications. Within this scope, one of …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …