Hyperuricemia is associated with an increased risk of gout, hypertension, diabetes, and
cardiovascular diseases. Most mammals maintain normal serum uric acid (SUA) via urate …

Recent advances and discoveries in the structure and role of mRNA as well as novel lipid-
based delivery modalities have enabled the advancement of mRNA therapeutics into the …

In recent years, the use of messenger RNA (mRNA) in the fields of gene therapy,
immunotherapy, and stem cell biomedicine has received extensive attention. With the …

Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …

RNA therapeutics represents a powerful strategy for diseases where other approaches have
failed, especially given the recent successes of mRNA vaccines against the coronavirus …

The coronavirus (COVID-19) pandemic has underscored the critical role of mRNA-based
vaccines as powerful, adaptable, readily manufacturable, and safe methodologies for …

Nucleic acid-based therapeutic molecules including small interfering RNA (siRNA),
microRNA (miRNA), antisense oligonucleotides (ASOs), messenger RNA (mRNA), and DNA …

Gene therapy has shown great potential to treat various diseases by repairing the abnormal
gene function. However, a great challenge in bringing the nucleic acid formulations to the …

Inflammatory microenvironments (IMEs) are common pathological characteristics and drive
the development of multiple chronic diseases. Thus, IME-targeted therapies exhibit potential …

Nucleic acid drugs, including antisense oligonucleotides (ASOs), have received
considerable attention as novel therapeutics for the treatment of intractable diseases …