Although small‐interfering RNAs (siRNAs) are specific silencers for numerous disease‐
related genes, their clinical applications still require safe and effective means of delivery into …

Rational design is pivotal in the modern development of nucleic acid nanocarrier systems.
With the rising prominence of polymeric materials as alternatives to lipid-based carriers …

Lipid-based nanoparticles have made a breakthrough in clinical disease as delivery
systems due to their biocompatibility, thermal and long-term stability, high loading ability …

RNA interference has become increasingly used for genetic therapy following the rapid
development of oligonucleotide drugs. Significant progress has been made in its delivery …

Cytoplasmic delivery of functional proteins into target cells remains challenging for many
biological agents to exert their therapeutic effects. Extracellular vesicles (EVs) are expected …

Vaccine development is among the critical issues for ceasing the COVID-19 pandemic. This
review discusses the current usage of biomaterials in vaccine development and provides …

The formation of noncovalent complexes by mixing of positively charged polymers with
negatively charged oligonucleotides (ONs) is a widely explored concept in nanomedicine to …

Since December 2019, a pandemic of COVID-19 disease, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread across the globe. At …

Inferior healing and peritendinous adhesions are the major clinical problems following
Achilles tendon injury, leading to impaired motor function and an increased risk of re …

Small interfering RNAs (siRNAs) are promising therapeutics for the treatment of human
diseases via the induction of sequence-specific gene silencing. To be functional, siRNAs …