Proteins undergoing liquid–liquid phase separation are being discovered at an increasing
rate. Since at the high concentrations present in the cell most proteins would be expected to …

Viral infection is controlled by host innate immune cells that express specialized receptors
for viral components. Engagement of these pattern recognition receptors triggers a series of …

Two prominent cytoplasmic RNA granules, ubiquitous RNA-processing bodies (PB) and
inducible stress granules (SG), regulate mRNA translation and are intimately related. In this …

Sex differences are pervasive in human health and disease. One major key to sex-biased
differences lies in the sex chromosomes. Although the functions of the X chromosome …

Significant recent advances in structural biology, particularly in the field of cryoelectron
microscopy, have dramatically expanded our ability to create structural models of proteins …

The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …

Multi-functional DEAD-box helicase 5 (DDX5), which is important in transcriptional
regulation, is hijacked by diverse viruses to facilitate viral replication. However, its regulatory …

Stress-induced tRNA fragmentation upon environmental insult is a conserved cellular
process catalysed by endonucleolytic activities targeting mature tRNAs. The resulting tRNA …

Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

This short review is focused on enzymatic properties of human ATP-dependent RNA
helicase DDX3 and the development of antiviral and anticancer drugs targeting cellular …