Targeting PI3K-AKT/mTOR signaling in the prevention of autism
A Sharma, S Mehan - Neurochemistry international, 2021 - Elsevier
Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …
for mammalian enzyme-related receptors in transducing signals or biological processes …
[HTML][HTML] The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …
[HTML][HTML] Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix
J Jia, J Chen, G Wang, M Li, Q Zheng, D Li - Biomedicine & …, 2023 - Elsevier
The traditional Chinese medicine (TCM) Rehmanniae Radix (RR) refers to the fresh or dried
root tuber of the plant Rehmannia glutinosa Libosch of the family Scrophulariaceae. As a …
root tuber of the plant Rehmannia glutinosa Libosch of the family Scrophulariaceae. As a …
Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of …
LK Wu, S Agarwal, CH Kuo, YL Kung, CH Day, PY Lin… - Phytomedicine, 2022 - Elsevier
Background Parkinson's disease (PD) is a neurodegenerative disorder involving the
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) …
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) …
Intranasally administered thermosensitive gel for brain-targeted delivery of rhynchophylline to treat Parkinson's disease
H Lin, L Xie, L Lv, J Chen, F Feng, W Liu, L Han… - Colloids and Surfaces B …, 2023 - Elsevier
The aim of this study is to overcome the obstacle of the blood-brain barrier (BBB) in
therapeutic drugs of Parkinson's disease (PD), like rhynchophylline (RIN) entry by intranasal …
therapeutic drugs of Parkinson's disease (PD), like rhynchophylline (RIN) entry by intranasal …
Polygonatum sibiricum Polysaccharides Protect against MPP‐Induced Neurotoxicity via the Akt/mTOR and Nrf2 Pathways
S Huang, H Yuan, W Li, X Liu, X Zhang… - Oxidative medicine …, 2021 - Wiley Online Library
Polygonatum sibiricum, a well‐known life‐prolonging tonic in Chinese medicine, has been
widely used for nourishing nerves in the orient, but the underlying molecular mechanisms …
widely used for nourishing nerves in the orient, but the underlying molecular mechanisms …
Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) cascade is a pleiotropic pathway that involves receptor subunit multimerization. The …
(STAT) cascade is a pleiotropic pathway that involves receptor subunit multimerization. The …
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism …
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder marked by
social and communication deficits as well as repetitive behaviour. Several studies have …
social and communication deficits as well as repetitive behaviour. Several studies have …
Neuroprotection of resveratrol against cadmium-poisoning acts through dual inhibition of mTORC1/2 signaling
C Liu, R Zhang, L Yang, T Ji, C Zhu, B Liu, H Zhang… - …, 2022 - Elsevier
Resveratrol is a natural polyphenol with neuroprotective function. The underlying
mechanism is not well understood. Our previous studies have identified that resveratrol …
mechanism is not well understood. Our previous studies have identified that resveratrol …
MicroRNA-185 activates PI3K/AKT signalling pathway to alleviate dopaminergic neuron damage via targeting IGF1 in Parkinson's disease
X Qin, X Zhang, P Li, M Wang, L Yan, P Pan… - Journal of drug …, 2021 - Taylor & Francis
Objectives Studies have extensively explored the role of microRNAs (miRs) in Parkinson's
disease (PD) and miR-185 is related to autophagy and apoptosis of dopaminergic neurons …
disease (PD) and miR-185 is related to autophagy and apoptosis of dopaminergic neurons …