Bacteria-mediated cancer therapy has become a topic of interest under the broad umbrella
of oncotherapy. Among many bacterial species, Salmonella remains at the forefront due to …

Prior to metastasis, modern therapeutics and surgical intervention can provide a favorable
long-term survival for patients diagnosed with many types of cancers. However, prognosis is …

Pannexins are a family of glycoproteins that comprises three members, PANX1, PANX2, and
PANX3. The widely expressed and interrogated PANX1 forms heptameric membrane …

Tunneling nanotubes (TNTs) are intercellular conduits, which meet the communication
needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred …

The expression, localization, and function of connexins, the protein subunits that comprise
gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap …

Exosomes are nanosized vesicles that carry biologically diverse molecules for intercellular
communication. Researchers have been trying to engineer exosomes for therapeutic …

Background Melanoma is a highly aggressive skin cancer with a poor prognosis and
mortality. Immune checkpoint blockade (ICB) therapy (eg, anti-PD-1 therapy) has opened a …

Connexin (Cx43)-formed channels have been linked to cardiac arrhythmias and diseases of
the heart associated with myocardial tissue loss and fibrosis. These pathologies include …

Immunotherapies for malignant melanoma seek to boost the anti‐tumoral response of CD8+
T cells, but have a limited patient response rate, in part due to limited tumoral immune cell …

Simple Summary Bystander effects depend on direct cell-cell communication and/or
paracrine signaling mediated by the release of soluble factors into the extracellular …