STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges
GL Wong, SG Manore, DL Doheny, HW Lo - Seminars in cancer biology, 2022 - Elsevier
Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …
The role of the ubiquitin-proteasome pathway in skin cancer development: 26S proteasome-activated NF-κB signal transduction
ABSTRACT The Ubiquitin-Proteasome System plays a central role in signal transduction
associated with stress, in the skin in particular by the control of NF-κB pathways. Under …
associated with stress, in the skin in particular by the control of NF-κB pathways. Under …
circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer
Y Yang, D Luo, Y Shao, Z Shan, Q Liu… - Cancer …, 2023 - Wiley Online Library
Abstract Background Circular RNAs (circRNAs) generated by back‐splicing of precursor
mRNAs (pre‐mRNAs) are often aberrantly expressed in cancer cells. Accumulating …
mRNAs (pre‐mRNAs) are often aberrantly expressed in cancer cells. Accumulating …
Echinacoside-Zinc nanomaterial inhibits skin glycation by suppressing the transcriptional activation of the receptor for advanced glycation end-products
J Han, Y Sun, T Wu, X Hou, S Zheng, H Zhang, T Lin… - ACS …, 2023 - ACS Publications
Glycation is a nonenzymatically catalyzed spontaneous reaction that eventually leads to the
formation of advanced glycation end-products (AGEs), which can bind to the receptor for …
formation of advanced glycation end-products (AGEs), which can bind to the receptor for …
[HTML][HTML] Synergy between BRD9-and IKZF3-Targeting as a Therapeutic Strategy for Multiple Myeloma
Progress in the treatment of multiple myeloma (MM) has resulted in improvement in the
survival rate. However, there is still a need for more efficacious and tolerated therapies. We …
survival rate. However, there is still a need for more efficacious and tolerated therapies. We …
[HTML][HTML] In silico and in vitro studies of novel cyanoacrylamides incorporating pyrazole moiety against breast and prostate carcinomas
FM Sroor, KF Mahrous, HI Shafey, NR Eid… - Medicinal Chemistry …, 2023 - Springer
We report novel cyanoacrylamide derivatives bearing the pyrazole moiety. The molecular
structures of the prepared cyanoacrylamides were confirmed by the different spectral tools …
structures of the prepared cyanoacrylamides were confirmed by the different spectral tools …
[HTML][HTML] Initial activation of STAT2 induced by IAV infection is critical for innate antiviral immunity
X Li, S Liu, KR Rai, W Zhou, S Wang, X Chi… - Frontiers in …, 2022 - frontiersin.org
STAT2 is an important transcription factor activated by interferons (IFNs) upon viral infection
and plays a key role in antiviral responses. Interestingly, here we found that phosphorylation …
and plays a key role in antiviral responses. Interestingly, here we found that phosphorylation …
Magnolin exhibits anti-inflammatory effects on chondrocytes via the NF-κB pathway for attenuating anterior cruciate ligament transection-induced osteoarthritis
K Xu, Y Gao, L Yang, Y Liu, C Wang - Connective tissue research, 2021 - Taylor & Francis
Purpose: This study aimed to investigate whether magnolin (MGL) possesses the capability
of suppressing inflammatory responses that can in turn alleviate osteoarthritis (OA) …
of suppressing inflammatory responses that can in turn alleviate osteoarthritis (OA) …
[HTML][HTML] Converging and evolving immuno-genomic routes toward immune escape in breast cancer
The interactions between tumor and immune cells along the course of breast cancer
progression remain largely unknown. Here, we extensively characterize multiple sequential …
progression remain largely unknown. Here, we extensively characterize multiple sequential …
Ex vivo mapping of enhancer networks that define the transcriptional program driving melanoma metastasis
V Manicardi, M Gugnoni, E Sauta, B Donati… - Molecular …, 2023 - Wiley Online Library
Mortality from vmelanoma is associated with metastatic disease, but the mechanisms
leading to spreading of the cancer cells remain obscure. Spatial profiling revealed that …
leading to spreading of the cancer cells remain obscure. Spatial profiling revealed that …