Revisiting the role of neurotransmitters in epilepsy: An updated review

E Akyuz, AK Polat, E Eroglu, I Kullu, E Angelopoulou… - Life sciences, 2021 - Elsevier
Epilepsy is a neurologicaldisorder characterized by persistent predisposition to recurrent
seizurescaused by abnormal neuronal activity in the brain. Epileptic seizures maydevelop …

Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?

PA Borea, S Gessi, S Merighi, K Varani - Trends in pharmacological …, 2016 - cell.com
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …

Focusing on adenosine receptors as a potential targeted therapy in human diseases

WI Effendi, T Nagano, K Kobayashi, Y Nishimura - Cells, 2020 - mdpi.com
Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

[HTML][HTML] Plant-derived antioxidants protect the nervous system from aging by inhibiting oxidative stress

X Cui, Q Lin, Y Liang - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) has become a major disease contributing to human death and is
thought to be closely related to the aging process. The rich antioxidant substances in plants …

[HTML][HTML] PET studies in epilepsy

I Sarikaya - American journal of nuclear medicine and molecular …, 2015 - ncbi.nlm.nih.gov
Various PET studies, such as measurements of glucose, serotonin and oxygen metabolism,
cerebral blood flow and receptor bindings are availabe for epilepsy. 18 Fluoro-2 …

Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases

D Vanda, P Zajdel, M Soural - European Journal of Medicinal Chemistry, 2019 - Elsevier
This article provides an overview of compounds based on imidazo [1, 2-a] pyridine, imidazo
[1, 5-a] pyridine, imidazo [4, 5-b] pyridine and imidazo [4, 5-c] pyridine scaffolds, which act as …

The role of the adenosine system in epilepsy and its comorbidities

JA Baltos, PM Casillas‐Espinosa… - British Journal of …, 2023 - Wiley Online Library
Epilepsy is one of the most serious and common chronic neurological conditions,
characterised by recurrent hypersynchronous electrical activity in the brain that lead to …

A unified hypothesis of SUDEP: Seizure‐induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and …

CL Faingold, HJ Feng - Epilepsia, 2023 - Wiley Online Library
Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in people with
epilepsy (PWE). Postictal apnea leading to cardiac arrest is the most common sequence of …

Real-time in vivo detection techniques for neurotransmitters: a review

Y Su, S Bian, M Sawan - Analyst, 2020 - pubs.rsc.org
Functional synapses in the central nervous system depend on a chemical signal exchange
process that involves neurotransmitter delivery between neurons and receptor cells in the …

ATPergic signalling during seizures and epilepsy

T Engel, M Alves, C Sheedy, DC Henshall - Neuropharmacology, 2016 - Elsevier
Much progress has been made over the last few decades in the identification of new anti-
epileptic drugs (AEDs). However, 30% of epilepsy patients suffer poor seizure control. This …