Sialic acid (SA), as the ultimate epitope of polysaccharides, can act as a cap at the end of
polysaccharide chains to prevent their overextension. Sialylation is the enzymatic process of …

Every eukaryotic cell is covered with a thick layer of complex carbohydrates with essential
roles in their social life. In Deuterostoma, sialic acids present at the outermost positions of …

Aberrant glycosylation is a universal feature of cancer cells, and cancer‐associated glycans
have been detected in virtually every cancer type. A common change in tumour cell …

Sialic acid isomers attached in either α2, 3 or α2, 6 linkage to glycan termini confer distinct
chemical, biological, and pathological properties, but they cannot be distinguished by mass …

Aberrant glycosylation is a hallmark of a cancer cell. One prevalent alteration is an
enrichment in α2, 6-linked sialylation of N-glycosylated proteins, a modification directed by …

Simple Summary Tumor cells accumulate sialylation in tissues via the coordination of
sialyltransferases and sialidases. Tumor sialylation can block receptor and ligand binding at …

Simple Summary The aberrant sialylation of membrane glycocalyx plays a pivotal role in the
regulation of malignant cell behavior and correlates with a worse prognosis and shorter …

Acute lymphoblastic leukemias arising from the malignant transformation of B-cell
precursors (BCP-ALLs) are protected against chemotherapy by both intrinsic factors as well …

Background Bone metastasis is a common consequence of advanced prostate cancer.
Bisphosphonates can be used to manage symptoms, but there are currently no curative …

Prion diseases are a group of fatal neurodegenerative diseases caused by misfolding of the
normal cellular form of the prion protein or PrPC, into a disease-associated self-replicating …