More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of 'omics' and …

Epithelial–mesenchymal transition (EMT) programs operate within carcinoma cells, where
they generate phenotypes associated with malignant progression. In their various …

The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …

Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …