[HTML][HTML] Targeting glutamine metabolism as a therapeutic strategy for cancer
Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …
Glutamine metabolism in breast cancer and possible therapeutic targets
S Li, H Zeng, J Fan, F Wang, C Xu, Y Li, J Tu… - Biochemical …, 2023 - Elsevier
Cancer is characterized by metabolic reprogramming, which is a hot topic in tumor treatment
research. Cancer cells alter metabolic pathways to promote their growth, and the common …
research. Cancer cells alter metabolic pathways to promote their growth, and the common …
[HTML][HTML] Slc6a14 and Slc38a5 drive the glutaminolysis and serine–Glycine–One-Carbon pathways in cancer
T Sniegowski, K Korac, YD Bhutia, V Ganapathy - Pharmaceuticals, 2021 - mdpi.com
The glutaminolysis and serine–glycine–one-carbon pathways represent metabolic reactions
that are reprogramed and upregulated in cancer; these pathways are involved in supporting …
that are reprogramed and upregulated in cancer; these pathways are involved in supporting …
Liposomal nanostructures for Gemcitabine and Paclitaxel delivery in pancreatic cancer
EK Silli, M Li, Y Shao, Y Zhang, G Hou, J Du… - European Journal of …, 2023 - Elsevier
Pancreatic cancer (PC) is an incurable disease with a high death rate in the world
nowadays. Gemcitabine (GEM) and Paclitaxel (PTX) are considered as references of …
nowadays. Gemcitabine (GEM) and Paclitaxel (PTX) are considered as references of …
Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis
S Sharma, N Agnihotri, S Kumar - Biochemical pharmacology, 2022 - Elsevier
Advances in cell metabolism over the past few decades have demonstrated glutamine as an
essential nutrient for cancer cell survival and proliferation. Glutamine offers a remarkable …
essential nutrient for cancer cell survival and proliferation. Glutamine offers a remarkable …
[HTML][HTML] Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
UD Mueez, VD de Mello, M Tuomainen, J Raiko… - Cell Reports, 2023 - cell.com
Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic
health. In murine BAT, cold increases the fundamental molecule for mitochondrial function …
health. In murine BAT, cold increases the fundamental molecule for mitochondrial function …
Expression and function of SLC38A5, an amino acid-coupled Na+/H+ exchanger, in triple-negative breast cancer and its relevance to macropinocytosis
S Ramachandran, S R. Sennoune… - Biochemical …, 2021 - portlandpress.com
Metabolic reprogramming in cancer necessitates increased amino acid uptake, which is
accomplished by up-regulation of specific amino acid transporters. However, not all tumors …
accomplished by up-regulation of specific amino acid transporters. However, not all tumors …
Clinical significance of carnitine in the treatment of cancer: from traffic to the regulation
Metabolic reprogramming is a common hallmark of cancer cells. Cancer cells exhibit
metabolic flexibility to maintain high proliferation and survival rates. In other words …
metabolic flexibility to maintain high proliferation and survival rates. In other words …
[HTML][HTML] The synergistic effects of the combination of L-carnitine and lycopene on the lycopene bioavailability and duodenal health of roosters
Simple Summary The objective of this study was to examine the effects of lycopene and L-
carnitine in combination in the duodenum of roosters. The duodenum is important for …
carnitine in combination in the duodenum of roosters. The duodenum is important for …
[HTML][HTML] Transporters at the interface between cytosolic and mitochondrial amino acid metabolism
Mitochondria are central organelles that coordinate a vast array of metabolic and biologic
functions important for cellular health. Amino acids are intricately linked to the bioenergetic …
functions important for cellular health. Amino acids are intricately linked to the bioenergetic …