Purpose: Activation of STING (s timulator of in terferon g enes) can trigger a robust, innate
antitumor immune response in immunologically “cold” tumors such as glioblastoma. Patients …

The cancer hazard associated with lifetime exposure to radiofrequency radiation (RFR) was
examined in Sprague Dawley (SD) rats at the Ramazzini Institute (RI), Italy. There were …

Glioblastoma multiforme (GBM) is a very aggressive and lethal primary brain cancer in
adults. The multifaceted nature of GBM pathogenesis, rising from complex interactions …

Simple Summary Canine oligodendrogliomas are universally fatal primary brain tumors.
Glioma-associated microglia/macrophages (GAMs) have been shown to contribute to …

9 Gene Editing and Gene Therapy in Oncology Page 1 9 Gene Editing and Gene Therapy
in Oncology WESLEY A. WIERSON 1*, ALEX M. ABEL 1, ELIZABETH L. SIEGLER 2 …

Cancer is a major cause of death in humans and animals worldwide. While cancer survival
rates have increased over recent decades, further research to identify risk factors for the …

Introduction The domestic dog, Canis familiaris, is quickly gaining traction as an
advantageous model for use in the study of cancer, one of the leading causes of death …

Background In humans, the T2‐weighted (T2W)—fluid‐attenuated inversion recovery
(FLAIR) mismatch sign (T2FMM) is a specific imaging biomarker for the isocitrate …

Canine glioma is a common brain tumor with poor prognosis despite surgery and/or
radiation therapy. Therefore, newer and more effective treatment modalities are needed …

High-grade oligodendroglioma (HGOG) is the most common type of glioma in dogs and
expresses platelet-derived growth factor receptor-α (PDGFR-α). Microvascular proliferation …