High‐grade glioma is an aggressive cancer that occurs naturally in pet dogs. Canine high‐
grade glioma (cHGG) is treated with radiation, chemotherapy or surgery, but has no curative …

Activation-induced cytidine deaminase, AICDA or AID, is a driver of somatic hypermutation
and class-switch recombination in immunoglobulins. In addition, this deaminase belonging …

Simple Summary Molecular biomarkers in cancer are measurable genomic alterations that
can indicate the risk of developing neoplasia, the presence of neoplastic cells, patient …

8 Cancer Immunotherapy Page 1 8 Cancer Immunotherapy NICOLA MASON 1* AND
STEVEN DOW 2* 1University of Pennsylvania, Philadelphia, Pennsylvania, USA; …

Naturally occurring canine cancers have remarkable similarities to their human counterparts.
In order to determine whether these similarities occur at the molecular level, we investigated …

A genomic understanding of the oncogenic processes and individual variability of human
cancer has steadily fueled improvement in patient outcomes over the past 20 years …

Background We previously reported a familial thyroid follicular cell carcinoma (FCC) in a
large number of Dutch German longhaired pointers and identified two deleterious germline …

Chronic kidney disease (CKD) affects 10% of the human population, with only a small
fraction genetically defined. CKD is also common in dogs and has been diagnosed in nearly …

Gliomas have an extremely poor prognosis in both adult and pediatric patient populations as
these tumors are known to grow aggressively and respond poorly to standard of care …

Spontaneous canine cancers are a valuable but relatively understudied and underutilized
model in cancer research. To enhance their usage, we reanalyzed whole exome …