Since the finding by Johnson and Ascher (1987) demonstrating that glycine enhances
electrophysiological responses mediated by N-methyl-D-aspartate (NMDA) b

THE GLUTAMATERGIC SYSTEM AND NEURODEGENERATION IN DEMENTIA: PREVENTIVE
STRATEGIES IN ALZHEIMER'S DISEASE Page 1 rNTCRNATIONAL JOURNAL OF GERIATRIC …

Human episodic memory refers to the recollection of an unique past experience in terms of
its details, its locale, and temporal occurrence. Episodic memory, even in principle, has been …

Object location task (OLT) has been used as a model of hippocampal-dependent memory.
Despite this application, there is neither a consistent pharmacological validation of NMDA …

Principaimente mediante esiudios que empiean el miedo condicionado pavloviano se ha
encontrado que la extinción del miedo condicionado es mediada por receptores de N-metil …

Abstract Background Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
(AMPA) modulators enhance glutamate transmission via the AMPA receptor by altering the …

The prevalence of Alzheimer's disease (AD) in the elderly is growing rapidly worldwide, and
the deteriorating clinical course of AD places a heavy burden on both the patients and their …

For decades neuroreceptor research has focused on the development of NMDA glycine-site
antagonists, after Johnson and Ascher found out in 1987 about the co-agonistic character of …

Temporal lobe epilepsy (TLE) patients are frequently afflicted with deficits in spatial and
other forms of declarative memory. This impairment is likely associated with the medial …

Amnesic properties of scopolamine, a muscarinic receptor antagonist, and MK-801, a non-
competitive N-methyl-d-aspartate (NMDA) receptor antagonist, were evaluated in mice by …