Abstract The phosphatidylinositol 3-kinase (PI3K) signalling pathway regulates cell survival,
proliferation, migration, metabolism and other vital cellular life processes. In addition …

Most solid cancer-related deaths result from metastasis, a multistep process in which cancer
cells exit the primary site, intravasate into the bloodstream, extravasate, and colonize distant …

Although temozolomide (TMZ) provides significant clinical benefit for glioblastoma (GBM),
responses are limited by the emergence of acquired resistance. Here, we demonstrate that …

Background Very young premenopausal women diagnosed with hormone receptor-positive,
human epidermal growth factor receptor 2-negative (HR+ HER2−) early breast cancer (EBC) …

Simple Summary PCNA is an interesting target for cancertreatment due to its essential
activities in DNA replication and repair and its recently discovered regulatory roles in cellular …

Immunity could be viewed as the common factor in neurodevelopmental disorders and
cancer. The immune and nervous systems coevolve as the embryo develops. Immunity can …

The class IA PI3K signaling pathway is activated by growth factor stimulation and regulates a
signaling cascade that promotes diverse events including cell growth, proliferation …

Background Propofol is a common sedative-hypnotic drug used for general anesthesia.
Recent studies have drawn attention to the antitumor effects of propofol, but the potential …

Colorectal cancer (CRC) is a common tumor with high morbidity and mortality. The use of
oxaliplatin (L‐OHP) as a first‐line treatment for CRC is limited due to chemoresistance …

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …