[HTML][HTML] A new therapeutic trend: natural medicine for ameliorating ischemic stroke via PI3K/Akt signaling pathway

X Liu, X Xiao, X Han, L Yao, W Lan - Molecules, 2022 - mdpi.com
Ischemic stroke (IS) is an acute cerebrovascular disease caused by sudden arterial
occlusion, which is characterized by a high morbidity, mortality, and disability rate. It is one of …

[HTML][HTML] The signaling pathways of traditional Chinese medicine in treating diabetic retinopathy

W Li, Q Xing, Z Liu, R Liu, Y Hu, Q Yan, X Liu… - Frontiers in …, 2023 - frontiersin.org
Diabetic retinopathy (DR) is one of the common diabetic microvascular complications that
occurs in the eyes and is closely associated with vision loss in working adults. However, the …

β-asarone improves cognitive impairment and alleviates autophagy in mice with vascular dementia via the cAMP/PKA/CREB pathway

Z Ning, X Zhong, Y Wu, Y Wang, D Hu, K Wang… - Phytomedicine, 2024 - Elsevier
Background Vascular dementia (VD) is the second most common type of dementia after
Alzheimer's disease. β-asarone, a major component of Acorus tatarinowii Schott, is …

Regulatory mechanisms of natural compounds from traditional Chinese herbal medicines on the microglial response in ischemic stroke

MH Ri, Y Xing, HX Zuo, MY Li, HL Jin, J Ma, X Jin - Phytomedicine, 2023 - Elsevier
Background Development of clinically effective neuroprotective agents for stroke therapy is
still a challenging task. Microglia play a critical role in brain injury and recovery after …

Baicalin reduces immune cell infiltration by inhibiting inflammation and protecting tight junctions in ischemic stroke injury

Z Hao, Z Zhang, Y Zhao, D Wang - The American Journal of …, 2023 - World Scientific
Ischemic stroke is a serious health hazard that lacks effective treatment strategies. This study
aims to investigate baicalin's effect on tight junctions and immune cell infiltration after …

[HTML][HTML] Exploring the Mechanism of Fufang Danshen Tablet against Atherosclerosis by Network Pharmacology and Experimental Validation

Y Liu, W Su, P Li, X Zeng, Y Zheng, Y Wang, W Peng… - Pharmaceuticals, 2024 - mdpi.com
Atherosclerosis is the main pathological basis of cardiovascular diseases (CVDs). Fufang
Danshen Tablet (FDT) is a traditional Chinese medicine that has been clinically used to treat …

[HTML][HTML] Danlou tablet attenuates ischemic stroke injury and blood‒brain barrier damage by inhibiting ferroptosis

C Liu, E Liu, Z Li, W Li, J Jin, H Sui, G Chen… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Danlou tablet (DLT) is a traditional Chinese medicinal
formulation known for replenishing Qi, promoting blood circulation, and resolving stasis. Its …

TMT-based quantitative proteomics reveals the protective mechanism of tenuigenin after experimental intracerebral hemorrhage in mice

P Wang, YQ Shen, A Manaenko, FY Liu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Tenuigenin (TNG) is an extract obtained from Polygalae
Radix. It possesses anti-inflammatory, antioxidant, and neuroprotective properties. However …

[HTML][HTML] Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology

JC Gomez-Verjan, EA Zepeda-Arzate… - Pharmaceuticals, 2023 - mdpi.com
Ischemic stroke (IS) is one of the leading causes of mortality worldwide. It is characterized by
the partial or total occlusion of arteries that supply blood to the brain, leading to the death of …

[HTML][HTML] The role of JAK/STAT signaling pathway in cerebral ischemia-reperfusion injury and the therapeutic effect of traditional Chinese medicine: A narrative review

T Song, Y Zhang, L Zhu, Y Zhang, J Song - Medicine, 2023 - journals.lww.com
Cerebral ischemia is a cerebrovascular disease with symptoms caused by insufficient blood
or oxygen supply to the brain. When blood supplied is restored after cerebral ischemia …