Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …

Most neurodegenerative disorders (NDD s) are characterized by cognitive impairment and
other neurological defects. The definite cause of and pathways underlying the progression …

Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and
could produce an “entourage effect” whereby they modulate cannabinoids to result in …

The endocannabinoid system (ECS) has been shown to be of great importance in the
regulation of numerous physiological and pathological processes. To date, two Class A G …

The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …

The endocannabinoid system (ECS) has been placed in the anti-cancer spotlight in the last
decade. The immense data load published on its dual role in both tumorigenesis and …

Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease”
electing multitarget compounds as potential therapeutic tools suitable for the treatment of …

Dysfunction of goal-directed behaviors under stressful or pathological conditions results in
impaired decision-making and loss of flexibility of thoughts and behaviors, which underlie …

Background It has been hypothesized that heteromers of adenosine A 2A receptors (A2AR)
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …

G protein-coupled receptors (GPCRs) are capable of interacting to form higher order
structures such as homomers and heteromers. Heteromerisation in particular has …