Endometrial receptivity in women of advanced age: an underrated factor in infertility

ADS Pathare, M Loid, M Saare, SB Gidlöf… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced
age is one of the critical risk factors for female-related infertility. It is well known that maternal …

Recurrent implantation failure: definition and management

C Coughlan, W Ledger, Q Wang, F Liu… - Reproductive …, 2014 - Elsevier
Recurrent implantation failure refers to failure to achieve a clinical pregnancy after transfer of
at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman …

Reconstituting the transcriptome and DNA methylome landscapes of human implantation

F Zhou, R Wang, P Yuan, Y Ren, Y Mao, R Li, Y Lian… - Nature, 2019 - nature.com
Implantation is a milestone event during mammalian embryogenesis. Implantation failure is
a considerable cause of early pregnancy loss in humans. Owing to the difficulty of obtaining …

Self-organization of the human embryo in the absence of maternal tissues

MN Shahbazi, A Jedrusik, S Vuoristo, G Recher… - Nature cell …, 2016 - nature.com
Remodelling of the human embryo at implantation is indispensable for successful
pregnancy. Yet it has remained mysterious because of the experimental hurdles that beset …

Deconstructing and reconstructing the mouse and human early embryo

MN Shahbazi, M Zernicka-Goetz - Nature cell biology, 2018 - nature.com
The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid …

Physiological and molecular determinants of embryo implantation

S Zhang, H Lin, S Kong, S Wang, H Wang… - Molecular aspects of …, 2013 - Elsevier
Embryo implantation involves the intimate interaction between an implantation-competent
blastocyst and a receptive uterus, which occurs in a limited time period known as the …

[HTML][HTML] Uterine fibroids and infertility

D Freytag, V Günther, N Maass, I Alkatout - Diagnostics, 2021 - mdpi.com
Infertility is a disease of the reproductive system defined by the failure to achieve a clinical
pregnancy after 12 months or more of regular unprotected sexual intercourse. Uterine …

Pathophysiological aspects of thyroid hormone disorders/thyroid peroxidase autoantibodies and reproduction

R Vissenberg, VD Manders… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Thyroid hormone disorders and thyroid peroxidase autoantibodies (TPO-
Ab) in women are associated with subfertility and early pregnancy loss. Here, we aim to …

What is the contribution of embryo-endometrial asynchrony to implantation failure?

WT Teh, J McBain, P Rogers - Journal of assisted reproduction and …, 2016 - Springer
Purpose The synchronized development of a viable embryo and a receptive endometrium is
critical for successful implantation to take place. The aim of this paper is to review current …

[HTML][HTML] An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF

YEM Koot, SR Van Hooff, CM Boomsma… - Scientific Reports, 2016 - nature.com
The primary limiting factor for effective IVF treatment is successful embryo implantation.
Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve …