Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Since the discovery of osteoinduction in the early 20th century, innovative biomaterials with
osteoinductive potential have emerged. Over the last 50 years, however, our ability to …

Observational studies have determined hyperphosphatemia to be a cardiovascular risk
factor in chronic kidney disease. Mechanistic studies have elucidated that …

The repair of large segmental bone defects due to trauma, inflammation and tumor surgery
remains a major clinical problem. Animal models were developed to test bone repair by …

The working hypothesis of guided bone regeneration (GBR) is that the membrane physically
excludes non-osteogenic tissues from interfering with bone healing. However, the …

The regeneration of tissues and organs poses an immense challenge due to the extreme
complexity in the research work involved. Despite the tissue engineering approach being …

Vascular calcification is a common problem among the elderly and those with chronic kidney
disease (CKD) and diabetes. The process of tunica media vascular calcification in CKD …

To understand early mineralization events, we studied living murine calvarial tissue by
Raman spectroscopy using fibroblast growth factor 2 (FGF2)-soaked porous beads. We …

Osteoporosis represents an important cause of morbidity in adult patients with thalassaemia
major (TM). The pathogenesis of osteoporosis in TM is multifactorial, and includes bone …

Orthopedic surgeons have long been troubled by cases involving nonunion of fractured
bones. This study aimed to enhance bone union by cell sheet transplantation of …