Innovative developments and emerging technologies in RNA therapeutics
ABSTRACT RNA-based therapeutics are emerging as a powerful platform for the treatment
of multiple diseases. Currently, the two main categories of nucleic acid therapeutics …
of multiple diseases. Currently, the two main categories of nucleic acid therapeutics …
Evolution of complexity in non-viral oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles
K Bakowski, S Vogel - RNA biology, 2022 - Taylor & Francis
From the early days of research on RNA biology and biochemistry, there was an interest to
utilize this knowledge and RNA itself for therapeutic applications. Today, we have a series of …
utilize this knowledge and RNA itself for therapeutic applications. Today, we have a series of …
Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo
Lipid conjugation supports delivery of small interfering RNAs (siRNAs) to extrahepatic
tissues, expanding the therapeutic potential of siRNAs beyond liver indications. However …
tissues, expanding the therapeutic potential of siRNAs beyond liver indications. However …
Recent trends in the delivery of RNA drugs: Beyond the liver, more than vaccine
RNAs are known for versatile functions and therapeutic utility. They have gained significant
interest since the approval of several RNA drugs, including COVID-19 mRNA vaccines and …
interest since the approval of several RNA drugs, including COVID-19 mRNA vaccines and …
Complexing the Pre-assembled Brush-like siRNA with Poly (β-amino ester) for Efficient Gene Silencing
X Liu, F Ding, Y Guo, K Jiang, Y Fu, L Zhu… - ACS Applied Bio …, 2022 - ACS Publications
Small interfering RNA (siRNA) has been emerging as a highly selective and effective
pharmaceutics for treating broad classes of diseases. However, the practical application of …
pharmaceutics for treating broad classes of diseases. However, the practical application of …
Identification of RNA fragments resulting from enzymatic degradation using MALDI-TOF mass spectrometry
SW Schowe, CJ Langeberg, EG Chapman… - JoVE (Journal of …, 2022 - jove.com
RNA is a biopolymer present in all domains of life, and its interactions with other molecules
and/or reactive species, eg, DNA, proteins, ions, drugs, and free radicals, are ubiquitous. As …
and/or reactive species, eg, DNA, proteins, ions, drugs, and free radicals, are ubiquitous. As …
The synthesis and in vitro evaluation of short interfering RNA containing triazole functionalized sphingolipid-based derivatives
CA Fernandez - 2021 - library-archives.canada.ca
RNA Interference (RNAi) is a natural cellular process that silences the expression of a target
gene in a sequence-specific manner by mediating targeted mRNA degradation. One of the …
gene in a sequence-specific manner by mediating targeted mRNA degradation. One of the …