Multi-site microbiota alteration is a hallmark of kidney stone formation

KF Al, BR Joris, BA Daisley, JA Chmiel, J Bjazevic… - Microbiome, 2023 - Springer
Background Inquiry of microbiota involvement in kidney stone disease (KSD) has largely
focussed on potential oxalate handling abilities by gut bacteria and the increased …

The microbiome of calcium-based urinary stones

RA Dornbier, P Bajic, M Van Kuiken, A Jardaneh, H Lin… - Urolithiasis, 2020 - Springer
Historically, the role of bacteria in urinary stone disease (USD) has been limited to urease-
producing bacteria associated with struvite stone formation. However, growing evidence has …

Profiling the urinary microbiome in men with calcium-based kidney stones

J Xie, J Huang, X Huang, J Peng, Z Yu, Y Yuan… - BMC microbiology, 2020 - Springer
Background The dogma that urine is sterile in healthy individuals has been overturned by
recent studies applying molecular-based methods. Mounting evidences indicate that …

Meta-analysis of clinical microbiome studies in urolithiasis reveal age, stone composition, and study location as the predominant factors in urolithiasis-associated …

N Kachroo, D Lange, KL Penniston, J Stern, G Tasian… - MBio, 2021 - Am Soc Microbiol
To determine whether functionally relevant questions associated with the urinary or gut
microbiome and urinary stone disease (USD) can be answered from metagenome-wide …

The urinary microbiota: a paradigm shift for bladder disorders?

L Brubaker, A Wolfe - Current Opinion in Obstetrics and …, 2016 - journals.lww.com
Deeper understanding of the FUM should yield better methods to restore the microbiota to a
healthy state, providing symptom relief. Opportunities to modify the FUM without antibiotic …

The bladder is not sterile: an update on the urinary microbiome

AL Ackerman, TC Chai - Current bladder dysfunction reports, 2019 - Springer
Abstract Purpose of Review The article discusses (1) techniques used to study bacterial
urinary microbiota;(2) existence of non-bacterial urinary microbiota;(3) associations between …

Standardization of microbiome studies for urolithiasis: an international consensus agreement

N Kachroo, D Lange, KL Penniston, J Stern… - Nature Reviews …, 2021 - nature.com
Numerous metagenome-wide association studies (MWAS) for urolithiasis have been
published, leading to the discovery of potential interactions between the microbiome and …

Escherichia coli Aggravates Calcium Oxalate Stone Formation via PPK1/Flagellin‐Mediated Renal Oxidative Injury and Inflammation

L An, W Wu, S Li, Y Lai, D Chen, Z He… - Oxidative medicine …, 2021 - Wiley Online Library
Escherichia coli (E. coli) is closely associated with the formation of kidney stones. However,
the role of E. coli in CaOx stone formation is not well understood. We explored whether E …

The renal pelvis urobiome in the unilateral kidney stone patients revealed by 2bRAD-M

SY Hong, YY Yang, JZ Xu, QD Xia, SG Wang… - Journal of Translational …, 2022 - Springer
Background The pathogenesis of kidney stone disease (KSD) is not fully understood, and
potential contributing factors remain to be explored. Several studies have revealed that the …

The role of microbiome: a novel insight into urolithiasis

SY Hong, QD Xia, YY Yang, C Li… - Critical Reviews in …, 2023 - Taylor & Francis
Urolithiasis, referred to as the formation of stones in the urinary tract, is a common disease
with growing prevalence and high recurrence rate worldwide. Although researchers have …