Regulation of microtubule dynamics, mechanics and function through the growing tip

NB Gudimchuk, JR McIntosh - Nature reviews Molecular cell biology, 2021 - nature.com
Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Stimuli-responsive polymer-based nanosystems for cancer theranostics

D Wei, Y Sun, H Zhu, Q Fu - ACS nano, 2023 - ACS Publications
Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen
species (ROS), glutathione (GSH), and pH, biological stimuli, such as enzymes, and external …

A comprehensive insight into fungal enzymes: Structure, classification, and their role in mankind's challenges

H El-Gendi, AK Saleh, R Badierah, EM Redwan… - Journal of Fungi, 2021 - mdpi.com
Enzymes have played a crucial role in mankind's challenges to use different types of
biological systems for a diversity of applications. They are proteins that break down and …

Strategies and lessons learned from total synthesis of taxol

L Min, JC Han, W Zhang, CC Gu, YP Zou… - Chemical …, 2023 - ACS Publications
Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …

A comprehensive review on graphene oxide-based nanocarriers: Synthesis, functionalization and biomedical applications

AD Sontakke, S Tiwari, MK Purkait - FlatChem, 2023 - Elsevier
The biomedical and nanomedicine sectors have bloomed in the last two decades with the
technological advancements in nanoscience. The significance of nanotechnology for …

Advancements in dextran-based nanocarriers for treatment and imaging of breast cancer

MS Khan, BHJ Gowda, N Nasir, S Wahab… - International journal of …, 2023 - Elsevier
Breast cancer is the most prevalent type of cancer worldwide, particularly among women,
with substantial side effects after therapy. Despite the availability of numerous therapeutic …

Molecular glue discovery: current and future approaches

JA Dewey, C Delalande, SA Azizi, V Lu… - Journal of medicinal …, 2023 - ACS Publications
The intracellular interactions of biomolecules can be maneuvered to redirect signaling,
reprogram the cell cycle, or decrease infectivity using only a few dozen atoms. Such …

Reconstitution of early paclitaxel biosynthetic network

JCT Liu, R De La Peña, C Tocol, ES Sattely - Nature Communications, 2024 - nature.com
Paclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades,
a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the …

Thymus vulgaris oil nanoemulsion: synthesis, characterization, antimicrobial and anticancer activities

AS Doghish, AM Shehabeldine, HA El-Mahdy… - Molecules, 2023 - mdpi.com
Essential oil nanoemulsions have received much attention due to their biological activities.
Thus, a thyme essential oil nanoemulsion (Th-nanoemulsion) was prepared using a safe …

Paclitaxel resistance related to nuclear envelope structural sturdiness

ER Smith, JQ Wang, DH Yang, XX Xu - Drug Resistance Updates, 2022 - Elsevier
Abstract Taxanes (Taxol/paclitaxel, Docetaxel/taxotere) are a key group of successful drugs
commonly used in chemotherapy to treat several major malignant tumors also as a front-line …