Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and
mammals but, in the last few decades, have shown to be capable of infecting humans as …

The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …

Viroporins are virus encoded proteins that alter membrane permeability and can trigger
subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a …

Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically
relevant animal viruses. When these proteins oligomerize in host cell membranes, they form …

Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …

Hepatitis E virus (HEV) is the leading cause of enterically transmitted viral hepatitis globally.
Of HEV's three ORFs, the function of ORF3 has remained elusive. Here, we demonstrate that …

Pestiviruses are among the economically most important pathogens of livestock. The biology
of these viruses is characterized by unique and interesting features that are both crucial for …

The coronavirus E protein is a small membrane protein that has an important role in the
assembly of virions. Recent studies have indicated that the E protein has functions during …

A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid
synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious …

Viroporins are indispensable for viral replication. As intracellular ion channels they disturb
pH gradients of organelles and allow Ca 2+ flux across ER membranes. Viroporins interact …