Conditional Cell Reprogramming and Air–Liquid Interface Modeling Life Cycle of Oncogenic Viruses (HPV and EBV) in Epithelial Cells and Virus-Associated Human …

AQ Rani, D Nurmemet, J Liffick, A Khan, D Mitchell, J Li… - Viruses, 2023 - mdpi.com
Several oncogenic viruses are associated with approximately 20% of human cancers.
Experimental models are crucial for studying the pathogenicity and biological aspects of …

[HTML][HTML] Conditional Cell Reprogramming in Modeling Digestive System Diseases

R Zhao, R Li, T An, X Liu - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Digestive diseases have become an important source of morbidity and mortality. The
considerable financial and health burdens caused by digestive diseases confirm the …

Human nasal epithelial cells (hnecs) generated by air-liquid interface (ALI) culture as a model system for studying the pathogenesis of SARS-COV-2

KS Tan, AM Gamage, J Liu - SARS-CoV-2: Methods and Protocols, 2022 - Springer
The nasal epithelium lining the human upper airway is the primary portal of entry for several
respiratory pathogens, including the recently emerged SARS-CoV-2 virus responsible for …

Identification of HPV oncogene and host cell differentiation associated cellular heterogeneity in cervical cancer via single‐cell transcriptomic analysis

Y Li, C Wang, A Ma, AQ Rani, M Luo… - Journal of Medical …, 2023 - Wiley Online Library
Abstract Human Papillomaviruses (HPVs) are associated with around 5%–10% of human
cancer, notably nearly 99% of cervical cancer. The mechanisms HPV interacts with stratified …

[HTML][HTML] Modeling human viral diseases: trials and triumphs

V Ayyavoo - Frontiers in Virology, 2021 - frontiersin.org
Understanding and studying human diseases caused by pathogens require tools other than
the natural host, as many diseases are lethal to humans. To understand the mechanism (s) …

Serially passaged, conditionally reprogrammed nasal epithelial cells as a model to study epithelial functions and SARS-CoV-2 infection

H Schmidt, L Guthjahr, A Sauter… - … of Physiology-Cell …, 2022 - journals.physiology.org
Primary airway epithelial cells (pAECs) cultivated at air-liquid interface (ALI) conditions are
widely used as surrogates for human in vivo epithelia. To extend the proliferative capacity …

[HTML][HTML] Making Cell Culture More Physiological: Serially passaged, conditionally reprogrammed nasal epithelial cells as a model to study epithelial functions and …

H Schmidt, L Guthjahr, A Sauter, F Zech… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Primary airway epithelial cells (pAECs) cultivated at air-liquid interface (ALI) conditions are
widely used as surrogates for human in vivo epithelia. To extend the proliferative capacity …

[HTML][HTML] Application of Organoids in Carcinogenesis Modeling and Tumor Vaccination

Z Wang, S Zhao, X Lin, G Chen, J Kang, Z Ma… - Frontiers in …, 2022 - frontiersin.org
Organoids well recapitulate organ specific functions from their tissue of origin, and remain
fundamental aspects of organogenesis. Organoids are widely applied in biomedical …

The role of ANO6/TMEM16F phospholipid scramblase in SARS-CoV-2 infection

심주리 - 2023 - ir.ymlib.yonsei.ac.kr
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is enveloped virus and has the Spike (S) glycoprotein on the virion envelope …

Serially passaged, conditionally reprogrammed nasal epithelial cells as a model to study epithelial functions and SARS‐CoV‐2 infection 2

MF Stenger, F Kirchhoff, P Dietl, OH Wittekindt… - journals.physiology.org
Primary airway epithelial cells (pAEC) cultivated at air‐liquid interface (ALI) conditions are
widely 25 used as surrogates for human in vivo epithelia. To extend the proliferative capacity …