Background: In 2004, the term acute kidney injury (AKI) was introduced with the intention of
broadening our understanding of rapid declines in renal function and to replace the …

Mitochondrial dysfunction is a key pathological event in many diseases. Its role in energy
production, calcium homeostasis, apoptosis regulation, and reactive oxygen species (ROS) …

Kidney tubular epithelial cells are high energy-consuming epithelial cells that depend
mainly on fatty acid oxidation for an energy supply. AMP-activated protein kinase (AMPK) is …

Emerging evidence implicates accelerated renal tubular epithelial cell (RTEC) senescence
in renal fibrosis progression. Mitophagy protects against kidney injury. However, the …

Renal proximal tubular cells are highly vulnerable to different types of assaults during
filtration and reabsorption, leading to acute renal dysfunction and eventual chronic kidney …

Extracellular vesicle (EV)‐based therapies have emerged as a promising means in
regenerative medicine. However, the conventional EV therapy strategy displays some …

Scientists have long established that fatty acids are the primary substrates for kidney
mitochondria. However, to date we still do not know how long-chain and middle-chain fatty …

Mitochondrial function, including oxidative phosphorylation (OXPHOS), mitochondrial
biogenesis, and mitochondria dynamics, are essential for the maintenance of renal health …

Acute kidney injury (AKI) significantly contributes to morbidity and mortality in critically ill
patients. AKI is also an independent risk factor for the development and progression of …

Aristolochic acid (AA), mainly derived from herbal Aristolochia and Asarum plants, was listed
as a human carcinogen class I in 2002. Aristolochic acid nephropathy (AAN) is a rapidly …