The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Dedifferentiation of insulin-secreting β cells in the islets of Langerhans has been proposed
to be a major mechanism of β-cell dysfunction. Whether dedifferentiated β cells can be …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

Understanding the biology underlying the mechanisms and pathways regulating pancreatic
β cell development is necessary to understand the pathology of diabetes mellitus (DM) …

Simple Summary This review highlights the scope of available treatment options for
neurological diseases, especially stem cell transplantation therapy, which provides new …

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such
diversity contributes to insulin release remains poorly understood. Here we show that subtle …