Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer

A Leonetti, B Wever, G Mazzaschi, YG Assaraf… - Drug Resistance …, 2019 - Elsevier
Immunotherapy has prompted a paradigm shift in advanced non-small cell lung cancer
(NSCLC) treatment, by demonstrating superior efficacy to chemotherapy alone both in …

[HTML][HTML] The role of tumor-associated macrophages in lung cancer: From mechanism to small molecule therapy

Y Zhou, M Qian, J Li, L Ruan, Y Wang, C Cai… - Biomedicine & …, 2024 - Elsevier
Tumor-associated macrophages (TAMs) are the main component of tumor-infiltrating
immune cells in the lung tumor microenvironment. TAMs recruited to the lung cancer can …

[HTML][HTML] Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions

J Russick, PE Joubert, M Gillard-Bocquet… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through
their cytotoxic effector functions and their capacity to interact with other immune cells to build …

[HTML][HTML] The mechanism and risk factors for immune checkpoint inhibitor pneumonitis in non-small cell lung cancer patients

X Zhai, J Zhang, Y Tian, J Li, W Jing… - Cancer Biology & …, 2020 - ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) are new and promising therapeutic agents for non-small
cell lung cancer (NSCLC). However, along with demonstrating remarkable efficacy, ICIs can …

18FDG PET/CT in the early assessment of non-small cell lung cancer response to immunotherapy: frequency and clinical significance of atypical evolutive patterns

O Humbert, N Cadour, M Paquet, R Schiappa… - European Journal of …, 2020 - Springer
Purpose This prospective study aimed (1) to assess the non-small cell lung cancer (NSCLC)
evolutive patterns to immunotherapy using FDG-PET and (2) to describe their association …

An integrated single-cell transcriptomic dataset for non-small cell lung cancer

KH Prazanowska, SB Lim - Scientific Data, 2023 - nature.com
As single-cell RNA sequencing (scRNA-seq) has emerged as a great tool for studying
cellular heterogeneity within the past decade, the number of available scRNA-seq datasets …

A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma

J Budczies, M Kirchner, K Kluck, D Kazdal… - …, 2021 - Taylor & Francis
Immune checkpoint blockade (ICB) expands the therapeutic options for metastatic lung
cancer nowadays representing a standard frontline strategy as monotherapy or combination …

The immune microenvironment in non‐small cell lung cancer is predictive of prognosis after surgery

ÅK Öjlert, AR Halvorsen, D Nebdal… - Molecular …, 2019 - Wiley Online Library
The impact of the tumor immune microenvironment on overall survival in non‐small cell lung
cancer (NSCLC) has been studied, but there is little information on its relevance for risk of …

Role of cytokines and chemokines in NSCLC immune navigation and proliferation

S Ramachandran, AK Verma, K Dev… - Oxidative medicine …, 2021 - Wiley Online Library
With over a million deaths every year around the world, lung cancer is found to be the most
recurrent cancer among all types. Nonsmall cell lung carcinoma (NSCLC) amounts to about …

Making cold malignant pleural effusions hot: driving novel immunotherapies

P Murthy, CN Ekeke, KL Russell, SC Butler… - …, 2019 - Taylor & Francis
Malignant pleural effusions, arising from either primary mesotheliomas or secondary
malignancies, heralds advanced disease and poor prognosis. Current treatments, including …