Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

PC Calder - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2015 - Elsevier
Inflammation is a condition which contributes to a range of human diseases. It involves a
multitude of cell types, chemical mediators, and interactions. Eicosapentaenoic acid (EPA) …

Impact of childhood malnutrition on host defense and infection

MK Ibrahim, M Zambruni, CL Melby… - Clinical microbiology …, 2017 - Am Soc Microbiol
The global impact of childhood malnutrition is staggering. The synergism between
malnutrition and infection contributes substantially to childhood morbidity and mortality …

Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

PC Calder - British journal of clinical pharmacology, 2013 - Wiley Online Library
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n‐3 fatty acids found in
oily fish and fish oil supplements. These fatty acids are able to inhibit partly a number of …

Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness

KR Levental, E Malmberg, JL Symons, YY Fan… - Nature …, 2020 - nature.com
Proper membrane physiology requires maintenance of biophysical properties, which must
be buffered from external perturbations. While homeostatic adaptation of membrane fluidity …

[HTML][HTML] Mechanisms of action of (n-3) fatty acids

PC Calder - The Journal of nutrition, 2012 - Elsevier
Abstract (n-3) PUFA are a family of biologically active fatty acids. The simplest member of
this family, a-linolenic acid, can be converted to the more biologically active very long-chain …

The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial

S Doaei, S Gholami, S Rastgoo… - Journal of translational …, 2021 - Springer
Background Omega-3 polyunsaturated fatty acids (n3-PUFAs) may exert beneficial effects
on the immune system of patients with viral infections. This paper aimed to examine the …

n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions

PC Calder - Proceedings of the Nutrition Society, 2013 - cambridge.org
Numerous effects of n-3 fatty acids EPA and DHA on functional responses of cells involved
in inflammation and immunity have been described. Fatty acid-induced modifications in …

The opposing effects of n− 3 and n− 6 fatty acids

G Schmitz, J Ecker - Progress in lipid research, 2008 - Elsevier
Polyunsaturated fatty acids (PUFAs) can be classified in n− 3 fatty acids and n− 6 fatty acids,
and in westernized diet the predominant dietary PUFAs are n− 6 fatty acids. Both types of …

Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease

N Fabelo, V Martín, G Santpere, R Marín, L Torrent… - Molecular …, 2011 - Springer
Lipid rafts are cholesterol-and sphingomyelin-enriched microdomains that provide a highly
saturated and viscous physico-chemical microenvironment to promote protein-lipid and …

Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease

JJ Liu, P Green, JJ Mann, SI Rapoport, ME Sublette - Brain research, 2015 - Elsevier
Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …