Diabetes is a chronic metabolic disease characterized by lack of insulin in the body leading
to failure of blood glucose regulation. Diabetes patients usually need frequent insulin …

Oral administration of insulin (INS) would represent a revolution in the treatment of diabetes,
considering that this route mimics the physiological dynamics of endogenous INS. Nano-and …

Diatoms are porous silica-based materials obtained from single cell photosynthetic algae.
Despite low cost, easy purification process, environmentally safe properties, and rapidly …

As diabetes is a complex disorder being a major cause of mortality and morbidity in
epidemic rates, continuous research has been done on new drug types and administration …

Oral delivery of insulin is blocked by low intestinal absorption caused by the poor
permeability of insulin across cellular membranes and the susceptibility to enzymatic …

To develop more effective anticancer mucoadhesive drug delivery system for the treatment
of colorectal cancer, chitosan based nanogels (NGs) were prepared by electrostatic …

Intestinal epithelium is a major barrier limiting the absorption of oral insulin owing to the
presence of intercellular tight junctions (TJs). Previous studies proved that carboxymethyl …

Proteins and peptides have a great potential as therapeutic agents; they have higher
efficiency and lower toxicity, compared to chemical drugs. However, their oral bioavailability …

Diabetes mellitus is an endocrine disease in which the pancreas does not produce sufficient
insulin or the body cannot effectively use the insulin it produces. Insulin therapy has been …

The small intestine provides the major site for the absorption of numerous orally
administered drugs. However, before reaching to the systemic circulation to exert beneficial …