[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis

J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …

Role of gut microbiota in identification of novel TCM-derived active metabolites

TL Lin, CC Lu, WF Lai, TS Wu, JJ Lu, YM Chen… - Protein & …, 2021 - academic.oup.com
Abstract Traditional Chinese Medicine (TCM) has been extensively used to ameliorate
diseases in Asia for over thousands of years. However, owing to a lack of formal scientific …

Quercetin attenuates atherosclerotic inflammation by inhibiting galectin‐3‐NLRP3 signaling pathway

H Li, L Xiao, H He, H Zeng, J Liu… - Molecular nutrition & …, 2021 - Wiley Online Library
Scope Atherosclerosis is the underlying pathogenesis of cardiovascular events caused by
inflammation, and dietary intervention has been recommended as one fundamental …

The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic

P Cao, S Wu, T Wu, Y Deng, Q Zhang, K Wang… - Carbohydrate …, 2020 - Elsevier
The new coronavirus pneumonia, named COVID-19 by the World Health Organization, has
become a pandemic. It is highly pathogenic and reproduces quickly. There are currently no …

Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways

Y Zhang, W Lu, X Zhang, J Lu, S Xu, S Chen… - Pharmacological …, 2019 - Elsevier
Cryptotanshinone (CTS), a lipophilic compound extracted from root of Salvia miltiorrhiza
(Danshen), has demonstrated multiple pharmacological activities, including anti …

[HTML][HTML] Lianhua Qingwen prescription for Coronavirus disease 2019 (COVID-19) treatment: Advances and prospects

LC Li, ZH Zhang, WC Zhou, J Chen, HQ Jin… - Biomedicine & …, 2020 - Elsevier
Abstract Background An outbreak of Coronavirus Disease 2019 (COVID-19) which was
infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is still …

[HTML][HTML] Drugs and targets in fibrosis

X Li, L Zhu, B Wang, M Yuan, R Zhu - Frontiers in pharmacology, 2017 - frontiersin.org
Fibrosis contributes to the development of many diseases and many target molecules are
involved in fibrosis. Currently, the majority of fibrosis treatment strategies are limited to …

[HTML][HTML] Indole-based small molecules as potential therapeutic agents for the treatment of fibrosis

R Qin, Q Zhao, B Han, HP Zhu, C Peng… - Frontiers in …, 2022 - frontiersin.org
Indole alkaloids are widely distributed in nature and have been particularly studied because
of their diverse biological activities, such as anti-inflammatory, anti-tumor, anti-bacterial, and …

Therapeutic potential of traditional Chinese medicine for interstitial lung disease

YM Zhou, XR Dong, D Xu, J Tang, YL Cui - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Interstitial lung disease (ILD) is a chronic lung dysfunction
disease with a poor prognosis and poor recovery. The clinically used therapeutic drugs …

[HTML][HTML] Hyperoside attenuates bleomycin-induced pulmonary fibrosis development in mice

J Huang, X Tong, L Zhang, Y Zhang, L Wang… - Frontiers in …, 2020 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal, and chronic lung disease. There
are no effective drug therapies for IPF. Hyperoside, a flavonoid glycoside, has been proven …