[HTML][HTML] Integrated bioinformatics and statistical approach to identify the common molecular mechanisms of obesity that are linked to the development of two …
Obesity is a chronic multifactorial disease characterized by the accumulation of body fat and
serves as a gateway to a number of metabolic-related diseases. Epidemiologic data indicate …
serves as a gateway to a number of metabolic-related diseases. Epidemiologic data indicate …
[HTML][HTML] Genomics of Dwarfism in Italian local chicken breeds
The identification of the dwarf phenotype in chicken is based on body weight, height, and
shank length, leaving the differentiation between dwarf and small breeds ambiguous. The …
shank length, leaving the differentiation between dwarf and small breeds ambiguous. The …
RGS6 mediates exercise-induced recovery of hippocampal neurogenesis, learning, and memory in an Alzheimer's mouse model
MM Spicer, J Yang, D Fu, AN DeVore, M Lauffer… - bioRxiv, 2023 - biorxiv.org
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer's disease (AD). Adult
hippocampal neurogenesis (AHN) is reduced in AD patients. Exercise stimulates AHN in …
hippocampal neurogenesis (AHN) is reduced in AD patients. Exercise stimulates AHN in …
Regulator of G protein signaling 6 (RGS6) in dopamine neurons promotes EtOH seeking, behavioral reward, and susceptibility to relapse
Mesolimbic dopamine (DA) transmission is believed to play a critical role in mediating
reward responses to drugs of abuse, including alcohol (EtOH). The neurobiological …
reward responses to drugs of abuse, including alcohol (EtOH). The neurobiological …
[HTML][HTML] Demographic and genome wide association analyses according to muscle mass using data of the korean genome and epidemiology study
Background Sarcopenia is commonly found in the elderly due to a decline in muscle mass.
Many researchers have performed genome-wide association studies (GWAS) to find genetic …
Many researchers have performed genome-wide association studies (GWAS) to find genetic …
A splice acceptor variant in RGS6 associated with intellectual disability, microcephaly, and cataracts disproportionately promotes expression of a subset of RGS6 …
KE Ahlers-Dannen, J Yang, MM Spicer, D Fu… - Journal of human …, 2024 - nature.com
Intellectual disability (ID) is associated with an increased risk of developing psychiatric
disorders, suggesting a common underlying genetic factor. Importantly, altered signaling …
disorders, suggesting a common underlying genetic factor. Importantly, altered signaling …
Regulator of G protein signaling 6 (RGS6) in ventral tegmental area (VTA) dopamine neurons promotes EtOH seeking, behavioral reward and susceptibility to relapse
Mesolimbic dopamine (DA) transmission is believed to play a critical role in mediating
reward responses to drugs of abuse, including alcohol (EtOH). EtOH is the most abused …
reward responses to drugs of abuse, including alcohol (EtOH). EtOH is the most abused …
Characterizing Molecular Alternations in Glioma Growth and Progression
VCJ Ye - 2023 - search.proquest.com
High grade gliomas (HGG) are incurable, aggressive brain malignances that occur in
patients of all ages. These cancers carry universally poor prognoses. Significant scientific …
patients of all ages. These cancers carry universally poor prognoses. Significant scientific …
[HTML][HTML] C5aR1 antagonism suppresses inflammatory glial gene expression and alters cellular signaling in an aggressive Alzheimer's model
ND Schartz, HY Liang, K Carvalho, SH Chu… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for
effective, sustainable therapeutic targets is imperative. Pharmacologic inhibition of C5aR1 …
effective, sustainable therapeutic targets is imperative. Pharmacologic inhibition of C5aR1 …