Mass spectrometry imaging (MSI) enables the direct analysis of molecules from the surface
of a wide variety of samples, allowing the multiplex measurement of both abundance and …

Our understanding of drug tissue distribution impacts a number of areas in drug
development, including: pharmacology, pharmacokinetics, safety, drug–drug interactions …

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-
MS) using organic matrices is a soft ionization technique that features minimal fragmentation …

Cassette dosing of compounds for preclinical drug plasma pharmacokinetic analysis has
been shown to be a powerful strategy within the pharmaceutical industry for increasing …

A new quantitation method for mass spectrometry imaging (MSI) with matrix‐assisted laser
desorption/ionization (MALDI) has been developed. In this method, drug concentrations …

The distributions of positron emission tomography (PET) ligands in rat brain tissue sections
were analyzed by matrix-assisted laser desorption/ionization mass spectrometry imaging …

In pharmaceutical research, understanding the biodistribution, accumulation and
metabolism of drugs in tissue plays a key role during drug discovery and development. In …

The CNS disposition and metabolism of Fosdevirine (FDV), an HIV non-nucleoside reverse
transcriptase inhibitor, was investigated in four patients who unexpectedly experienced …

Mass spectrometry imaging (MSI) is a rapidly evolving technology that yields qualitative and
quantitative distribution maps of small pharmaceutical-active molecules and their …

The rapid and direct analysis of the amount and spatial distribution of exogenous
chloroquine (CHQ) and CHQ metabolites from tissue sections by liquid extraction surface …