Molecular genetics and diagnosis of thyroid cancer
YE Nikiforov, MN Nikiforova - Nature Reviews Endocrinology, 2011 - nature.com
Thyroid cancer is a common type of endocrine malignancy, and its incidence has been
steadily increasing in many regions of the world. Initiation and progression of thyroid cancer …
steadily increasing in many regions of the world. Initiation and progression of thyroid cancer …
Progress in molecular-based management of differentiated thyroid cancer
M Xing, BR Haugen, M Schlumberger - The Lancet, 2013 - thelancet.com
Substantial developments have occurred in the past 5–10 years in clinical translational
research of thyroid cancer. Diagnostic molecular markers, such as RET-PTC, RAS, and …
research of thyroid cancer. Diagnostic molecular markers, such as RET-PTC, RAS, and …
Mortality risk stratification by combining BRAF V600E and TERT promoter mutations in papillary thyroid cancer: genetic duet of BRAF and TERT promoter mutations in …
Importance BRAF V600E andTERTpromoter mutations can coexist in papillary thyroid
cancer (PTC). This genetic duet was indicated to be involved in the aggressiveness of PTC …
cancer (PTC). This genetic duet was indicated to be involved in the aggressiveness of PTC …
The Increase in Thyroid Cancer Incidence During the Last Four Decades Is Accompanied by a High Frequency of BRAF Mutations and a Sharp Increase in RAS …
Context: Thyroid cancer incidence rates in the United States and globally have increased
steadily over the last 40 years, primarily due to a tripling of the incidence of papillary thyroid …
steadily over the last 40 years, primarily due to a tripling of the incidence of papillary thyroid …
Senescent tumor cells lead the collective invasion in thyroid cancer
Cellular senescence has been perceived as a barrier against carcinogenesis. However, the
senescence-associated secretory phenotype (SASP) of senescent cells can promote …
senescence-associated secretory phenotype (SASP) of senescent cells can promote …
TERT Promoter Mutations and Their Association with BRAF V600E Mutation and Aggressive Clinicopathological Characteristics of Thyroid Cancer
Context: Promoter mutations chr5: 1,295,228 C> T and chr5: 1,295,250 C> T (termed C228T
and C250T, respectively) in the gene for telomerase reverse transcriptase (TERT) have …
and C250T, respectively) in the gene for telomerase reverse transcriptase (TERT) have …
Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas
C Montero-Conde, S Ruiz-Llorente, JM Dominguez… - Cancer discovery, 2013 - AACR
The RAF inhibitor vemurafenib (PLX4032) increases survival in patients with BRAF-mutant
metastatic melanoma, but has limited efficacy in patients with colorectal cancers. Thyroid …
metastatic melanoma, but has limited efficacy in patients with colorectal cancers. Thyroid …
[HTML][HTML] Anti-tumour effects of lanreotide for pancreatic and intestinal neuroendocrine tumours: the CLARINET open-label extension study
ME Caplin, M Pavel, JB Ćwikła, AT Phan… - Endocrine-related …, 2016 - erc.bioscientifica.com
In the CLARINET study, lanreotide Autogel (depot in USA) significantly prolonged
progression-free survival (PFS) in patients with metastatic pancreatic/intestinal …
progression-free survival (PFS) in patients with metastatic pancreatic/intestinal …
The association of the BRAFV600E mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: A meta‐analysis
BACKGROUND: The effects of the BRAFV600E mutation on prognostic factors and poor
clinical outcomes in papillary thyroid cancer (PTC) have not been fully quantified. The …
clinical outcomes in papillary thyroid cancer (PTC) have not been fully quantified. The …
Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules
YE Nikiforov, DL Steward… - The Journal of …, 2009 - academic.oup.com
Context: Thyroid nodules are common in adults, but only a small fraction of them are
malignant. Fine-needle aspiration (FNA) with cytological evaluation is the most reliable tool …
malignant. Fine-needle aspiration (FNA) with cytological evaluation is the most reliable tool …