Patients with poorly differentiated thyroid cancers (PDTC), anaplastic thyroid cancers (ATC),
and radioactive iodine-refractory (RAIR) differentiated thyroid cancers have a high mortality …

Clinicians have long sought to characterize biological markers of neoplasia as objective
indicators of tumor presence, pathogenicity, and prognosis. Armed with data that correlate …

Background: The BRAFV600E mutation is the most frequent genetic alteration in papillary
thyroid carcinoma (PTC). The role of BRAFV600E mutation as a poor prognostic factor has …

Background: Aberrant activation of the phosphatidylinositol-3 kinase (PI3K)/Akt pathway
plays a fundamental role in thyroid tumorigenesis, particularly in follicular thyroid cancer …

Context.—Thyroid cancer is the most common type of endocrine malignancy and its
incidence is steadily increasing. Papillary carcinoma and follicular carcinoma are the most …

Context: Genetic alterations in receptor tyrosine kinases (RTKs) and phosphatidylinositol 3-
kinase (PI3K)/Akt and MAPK pathways have not been fully defined in anaplastic and …

Background: The accuracy of cancer detection in thyroid nodules by fine-needle aspiration
(FNA) cytology and prognostication of thyroid cancer needs further improvement and can …

Background: The BRAF V600E mutation, the most frequent genetic alteration in papillary
thyroid carcinoma (PTC), was demonstrated to be a poor prognostic factor. The aim of this …

RAS Mutations in Thyroid Cancer | The Oncologist | Oxford Academic Skip to Main Content
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Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. It shows a
wide spectrum of morphological presentations and the diagnosis could be challenging due …