The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing
directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a …

Mitochondria are the powerhouse of the cell and dynamically control fundamental biological
processes including cell reprogramming, pluripotency, and lineage specification. Although …

Disorders characterized by ischemia/reperfusion (I/R) are the most common causes of
debilitating diseases and death in stroke, cardiovascular ischemia, acute kidney injury or …

Tumor-derived exosomes are emerging mediators of cancer cachexia. Clarifying the
regulation of exosome biogenesis and finding possible targets for cancer cachexia therapy …

Dysregulation of deubiquitination has been reported to contribute to carcinogenesis.
However, the function and mechanism of deubiquitinating enzyme 26S proteasome non …

Abstract Pyruvate kinase M2 (PKM2), a glycolytic rate-limiting enzyme, reportedly plays an
important role in tumorigenesis and the inflammatory response by regulating the metabolic …

Metabolic dysfunction associated with fatty liver disease (MAFLD), always accompanied by
disturbance of glucose and lipid metabolism, is becoming the most difficult obstacle in the …

Neutrophils (polymorphonuclear leukocytes, PMNs) have a distinctively short lifespan, and
tight regulation of cell survival and death is imperative for their normal function. We …

Gliomas are considered one of the most malignant tumors in the body. The immune system
has the ability to control the initiation and development of tumors, including gliomas. Thus …

The allosteric regulation of pyruvate kinase M2 (PKM2) affects the switching of the PKM2
protein between the high-activity and low-activity states that allow ATP and lactate …