Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively
associated with cardiovascular and neurodegenerative diseases. However, findings from …

Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …

Sialic acid sugar-carrying glycans, sialoglycans, are aberrantly expressed on many tumor
cells and have emerged as potent regulatory molecules involved in creating a tumor …

Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …

Background Glycans play essential functional roles in the nervous system and their
pathobiological relevance has become increasingly recognized in numerous brain …

Galectins, the glycan binding proteins, and their respective carbohydrate ligands represent a
unique fundamental regulatory network modulating a plethora of biological processes. The …

Galectins are β-galactoside-binding lectins consisting of 15 members in mammals. Galectin-
1,-3,-4,-8, and-9 are predominantly expressed in the central nervous system (CNS) and …

Galectin-3 (Gal-3) participates in many cancer-related metabolic processes. The inhibition of
overexpressed Gal-3 by, eg, β-galactoside-derived inhibitors is hence promising for cancer …

Epithelial cell adhesion molecule (EpCAM), which is a transmembrane glycoprotein, is
related to tumor progression. We demonstrated that EpCAM plays important roles in …

Galectins are proteins of the family of human lectins. By binding terminal galactose units of
cell surface glycans, they moderate biological and pathological processes such as cell …