Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent
complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age …

The maintenance of iron homeostasis is essential for proper endocrine function. A growing
body of evidence suggests that iron imbalance is a key factor in the development of several …

Extracellular communication, in other words, crosstalk between cells, has a pivotal role in
the survival of an organism. This communication occurs by different methods, one of which is …

Hematologic malignancies (HMs) mainly include acute and chronic leukemia, lymphoma,
myeloma and other heterogeneous tumors that seriously threaten human life and health …

Spinal cord injury (SCI) is an extreme neurological impairment with few effective drug
treatments. Pyroptosis is a recently found and proven type of programmed cell death that is …

Background Hepatocellular carcinoma (HCC) is a common cancer worldwide, and sorafenib
is a first-line drug for the treatment of advanced liver cancer. Resistance to sorafenib has …

Hypoxia‐inducible factor (HIF) plays a critical role in the mechanisms that allow cells to
adapt to various oxygen levels in the environment. Specifically, HIF‐1⍺ has shown to be …

Abstract Context Metformin (Met) has a protective effect against cardiac ischemia and
reperfusion (I/R) injury. Objective This study uncovered the Met effect on ferroptosis in …

Studies examining the regulatory roles and clinical applications of monosaccharides other
than glucose in cancer have been neglected. Mannose, a common type of monosaccharide …

Background Metformin is the most frequently prescribed medication for the treatment of type
II diabetes mellitus and has played an anti-tumor potential in a variety of cancer types …